Evidence map›Paper›PMID 40224528›Full record

ReviewJournal of diabetes and metabolic disorders2025

Artificial intelligence for early detection of diabetes mellitus complications via retinal imaging.

Navid Sobhi, Yasin Sadeghi-Bazargani, Majid Mirzaei, Mirsaeed Abdollahi, Ali Jafarizadeh, Siamak Pedrammehr, Roohallah Alizadehsani, Ru-San Tan, Sheikh Mohammed Shariful Islam, U Rajendra Acharya

Abstract readReview
In one paragraph

Review in Journal of diabetes and metabolic disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. A Review of the Use of Artificial Intelligence in Ophthalmology Imaging: Approximation to Ocular Histopathology.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026
    Review
  2. Artificial intelligence in diabetic retinopathy: from automated screening to risk-stratified care.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Navid Sobhi *Nikookari Eye Center, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0003-0663-850X
Yasin Sadeghi-Bazargani *Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0003-2175-1316
Majid Mirzaei *Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0003-3573-6985
Mirsaeed AbdollahiNikookari Eye Center, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0002-2444-1172
Ali JafarizadehNikookari Eye Center, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0003-4922-1923
Siamak PedrammehrInstitute for Intelligent Systems Research and Innovation (IISRI), Deakin University, 75 Pigdons Rd, Waurn Ponds, VIC 3216 Australia.ORCID https://orcid.org/0000-0002-2974-1801
Roohallah AlizadehsaniInstitute for Intelligent Systems Research and Innovation (IISRI), Deakin University, 75 Pigdons Rd, Waurn Ponds, VIC 3216 Australia.ORCID https://orcid.org/0000-0003-0898-5054
Ru-San TanNational Heart Centre Singapore, Singapore, Singapore.ORCID https://orcid.org/0000-0003-2086-6517
Sheikh Mohammed Shariful IslamInstitute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Melbourne, VIC Australia.ORCID 0000-0001-7926-9368
U Rajendra AcharyaSchool of Mathematics, Physics, and Computing, University of Southern Queensland, Springfield, QLD 4300 Australia.ORCID https://orcid.org/0000-0003-2689-8552

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diabetes mellitus (DM) increases the risk of vascular complications, and retinal vasculature imaging serves as a valuable indicator of both microvascular and macrovascular health. Moreover, artificial intelligence (AI)-enabled systems developed for high-throughput detection of diabetic retinopathy (DR) using digitized retinal images have become clinically adopted. This study reviews AI applications using retinal images for DM-related complications, highlighting advancements beyond DR screening, diagnosis, and prognosis, and addresses implementation challenges, such as ethics, data privacy, equitable access, and explainability. Methods: We conducted a thorough literature search across several databases, including PubMed, Scopus, and Web of Science, focusing on studies involving diabetes, the retina, and artificial intelligence. We reviewed the original research based on their methodology, AI algorithms, data processing techniques, and validation procedures to ensure a detailed analysis of AI applications in diabetic retinal imaging. Results: Retinal images can be used to diagnose DM complications including DR, neuropathy, nephropathy, and atherosclerotic cardiovascular disease, as well as to predict the risk of cardiovascular events. Beyond DR screening, AI integration also offers significant potential to address the challenges in the comprehensive care of patients with DM. Conclusion: With the ability to evaluate the patient's health status in relation to DM complications as well as risk prognostication of future cardiovascular complications, AI-assisted retinal image analysis has the potential to become a central tool for modern personalized medicine in patients with DM.

Indexed as

Artificial intelligenceDiabetes complicationsDiabetes mellitusDiabetic retinopathyRetina

Identifiers

PMID40224528
PMCPMC11993533

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.