Evidence map›Paper›PMID 40224474›Full record

ArticleACS omega2025

Optimization of Capillary Vibrating Sharp-Edge Spray Ionization for Native Mass Spectrometry of Triplex DNA.

Sultan Mahmud, Vikum K Dewasurendra, Chandrima Banerjee, Pedram Tavadze, Mst Nigar Sultana, Mohammad A Rahman, Sohag Ahmed, Peng Li, Matthew B Johnson, Stephen J Valentine

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sultan MahmudDepartment of Chemistry, West Virginia University, Morgantown, West Virginia 26506, United States.
Vikum K DewasurendraDepartment of Physics and Astronomy, West Virginia University, Morgantown, West Virginia 26506, United States.ORCID https://orcid.org/0000-0003-3000-4195
Chandrima BanerjeeDepartment of Chemistry, West Virginia University, Morgantown, West Virginia 26506, United States.
Pedram TavadzeDepartment of Physics and Astronomy, West Virginia University, Morgantown, West Virginia 26506, United States.
Mst Nigar SultanaDepartment of Chemistry, West Virginia University, Morgantown, West Virginia 26506, United States.
Mohammad A RahmanDepartment of Chemistry, West Virginia University, Morgantown, West Virginia 26506, United States.
Sohag AhmedDepartment of Chemistry, West Virginia University, Morgantown, West Virginia 26506, United States.
Peng LiDepartment of Chemistry, West Virginia University, Morgantown, West Virginia 26506, United States.ORCID https://orcid.org/0000-0002-8332-7142
Matthew B JohnsonDepartment of Physics and Astronomy, West Virginia University, Morgantown, West Virginia 26506, United States.
Stephen J ValentineDepartment of Chemistry, West Virginia University, Morgantown, West Virginia 26506, United States.ORCID https://orcid.org/0000-0003-4360-2928

Funding

Developing an integrated system for detailing the conformational flexibility, heterogeneity, and dynamics of functional oligonucleotidesR01GM153899 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Peng Li, Aaron Reigh Robart · 2024 to 2026
$1.5M
NIGMS NIH HHS R01 GM153899
6 · The paper itself

Abstract

Capillary vibrating sharp-edge spray ionization (cVSSI) has been used to study the effects of applied voltage and mass spectrometer heated inlet transfer tube temperature on DNA triplex ion production for native mass spectrometry (MS) samples. Overall, medium applied voltage (-900 to -1000 V) results in better ion production of the desired triplex ions (Tri) (i.e., those without cation adducts such as NH

Identifiers

PMID40224474
PMCPMC11983206

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.