Evidence map›Paper›PMID 40224467›Full record

ArticleACS omega2025

Xuanfei Baidu Decoction Alleviated Sepsis-Induced ALI by Modulating Gut Microbial Homeostasis and Promoting Inflammation Resolution: Bioinformatics and Experimental Study.

Lei Yang, Sijia Zhang, Lingzhi Cui, Junxia Zhang, Shukun Zhang, Lanqiu Zhang, Lihua Cui, Caixia Li, Yuzhen Zhuo, Yuhong Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lei YangTianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Hospital of Integrated Chinese and Western Medicine, Tianjin University, Tianjin 300100, China.
Sijia ZhangGraduate School, Tianjin Medical University, Tianjin 300270, China.ORCID https://orcid.org/0000-0003-2606-6721
Lingzhi CuiGraduate School, Tianjin Medical University, Tianjin 300270, China.
Junxia ZhangGraduate School, Tianjin Medical University, Tianjin 300270, China.
Shukun ZhangTianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Hospital of Integrated Chinese and Western Medicine, Tianjin University, Tianjin 300100, China.
Lanqiu ZhangTianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Hospital of Integrated Chinese and Western Medicine, Tianjin University, Tianjin 300100, China.
Lihua CuiTianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Hospital of Integrated Chinese and Western Medicine, Tianjin University, Tianjin 300100, China.
Caixia LiTianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Hospital of Integrated Chinese and Western Medicine, Tianjin University, Tianjin 300100, China.
Yuzhen ZhuoTianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Hospital of Integrated Chinese and Western Medicine, Tianjin University, Tianjin 300100, China.ORCID https://orcid.org/0000-0002-9723-0165
Yuhong LiInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.ORCID https://orcid.org/0000-0002-2358-5449
Ximo WangTianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Hospital of Integrated Chinese and Western Medicine, Tianjin University, Tianjin 300100, China.ORCID https://orcid.org/0000-0002-8070-6999

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Xuanfei Baidu Decoction (XFBD) has shown effective therapeutic potential for acute lung injury (ALI) induced by lipopolysaccharide and immunoglobin G immune complexes. Herein, the protective effects and mechanisms of XFBD were investigated in a sepsis-induced ALI mouse model along with its effects on gut microbiota. Notably, bioinformatics and molecular docking analyses revealed that XFBD components exhibited a strong binding affinity to G-protein-coupled receptor 18 (GPR18). In the murine ALI model-induced by cecal ligation and puncture (CLP)-XFBD markedly improved lung histopathology, reduced M1 macrophage polarization, and decreased pro-inflammatory cytokine levels in both lung tissues and MH-S macrophages. Furthermore, XFBD downregulated key inflammatory pathways, including nuclear factor (NF)-κB, phosphorylated-NF-κB, CCAAT/enhancer binding protein-δ, and the nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 3/Caspase-1/gasdermin D axis. Additionally, XFBD restored the CLP-induced disruption in gut microbiota balance, increasing the abundance of Prevotellaceae and Ruminococcaceae_UCG_014. Altogether, the findings of this study suggest that XFBD alleviates CLP-induced ALI by modulating gut microbial homeostasis and inhibiting associated inflammatory pathways, particularly via GPR18 activation, presenting the promising therapeutic potential of XFBD for treating sepsis-induced ALI.

Identifiers

PMID40224467
PMCPMC11983172

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.