ArticleACS omega2025
Advancements in Noninvasive Volatile Organic Compound Detection: Integrating Stirling Cooling Preconcentration with GC-FID/MS for Quantitative Breath Analysis.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The study of volatile organic compounds (VOCs) in exhaled breath presents significant potential for noninvasive disease diagnosis and human exposure monitoring. While thermal desorption (TD) tubes are the most commonly used preconcentration technique for analyzing VOCs in breath, they still face practical challenges, mainly selective adsorption and interference from water vapor in breath samples. This study is the first to develop a method combining Stirling cooling preconcentration technology with gas chromatography-flame ionization detector/mass spectrometry (GC-FID/MS) and a SUMMA canister, enabling simultaneous detection of 116 VOCs. The method requires no refrigerants and effectively addresses the selective adsorption and water vapor interference issues found with TD tubes. Furthermore, nitrogen pressurization is used to dilute the original gas, and calibration curves encompassing various linear ranges are developed to quantify the targeted VOCs across different concentration levels. Finally, we analyzed exhaled breath samples from eight healthy subjects and validated the method. The results showed that the coefficients of determination (
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