Evidence map›Paper›PMID 40224406›Full record

ArticleACS omega2025

Dimethyl Sulfate as Methylation Agent and Solvent in Highly Regioselective Synthesis of Methyl Salicylate Using Sodium Bicarbonate as a Base.

Milton de Souza Freitas, David Lee Nelson, João Victor G de Sousa, Alexandre P Wentz, Dayane B Tada, Rafaela C Queiroz, Carolina R Hurtado, Erenilda F de Macedo, Katia Conceição, Gabriela R Hurtado and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Milton de Souza FreitasDepartment of Pharmacy, Universidade Federal dos Vales do Jequitinhonha e Mucuri-UFVJM, Campus JK, Rodovia MGT 367 - Km 583, n° 5.000, Alto da Jacuba, CEP 39100-000 Diamantina, MG, Brazil.
David Lee NelsonDepartment of Pharmacy, Universidade Federal dos Vales do Jequitinhonha e Mucuri-UFVJM, Campus JK, Rodovia MGT 367 - Km 583, n° 5.000, Alto da Jacuba, CEP 39100-000 Diamantina, MG, Brazil.
João Victor G de SousaDepartment of Pharmacy, Universidade Federal dos Vales do Jequitinhonha e Mucuri-UFVJM, Campus JK, Rodovia MGT 367 - Km 583, n° 5.000, Alto da Jacuba, CEP 39100-000 Diamantina, MG, Brazil.
Alexandre P WentzDepartment of Pharmacy, Universidade Federal dos Vales do Jequitinhonha e Mucuri-UFVJM, Campus JK, Rodovia MGT 367 - Km 583, n° 5.000, Alto da Jacuba, CEP 39100-000 Diamantina, MG, Brazil.
Dayane B TadaNanomaterials and Nanotoxicology Laboratory, Institute of Science and Technology, Federal University of São Paulo (UNIFESP), R. Talim, 330, Vila Nair, CEP 12231-280 São José dos Campos, SP, Brazil.
Rafaela C QueirozNanomaterials and Nanotoxicology Laboratory, Institute of Science and Technology, Federal University of São Paulo (UNIFESP), R. Talim, 330, Vila Nair, CEP 12231-280 São José dos Campos, SP, Brazil.
Carolina R HurtadoNanomaterials and Nanotoxicology Laboratory, Institute of Science and Technology, Federal University of São Paulo (UNIFESP), R. Talim, 330, Vila Nair, CEP 12231-280 São José dos Campos, SP, Brazil.
Erenilda F de MacedoNanomaterials and Nanotoxicology Laboratory, Institute of Science and Technology, Federal University of São Paulo (UNIFESP), R. Talim, 330, Vila Nair, CEP 12231-280 São José dos Campos, SP, Brazil.
Katia ConceiçãoPeptide Biochemistry Laboratory, Institute of Science and Technology, Federal University of São Paulo (Unifesp), R. Talim, 330, Vila Nair, CEP 12231-280 São José dos Campos, SP, Brazil.
Gabriela R HurtadoInstitute of Science and Technology, São Paulo State University (UNESP), Rod. Pres. Dutra, km 137,8, Eugênio de Melo, CEP 12247-004 São José dos Campos, SP, Brazil.
Fernando L P PessoaCentro Universitário SENAI-CIMATEC, Av. Orlando Gomes, 1845, Piatã, Salvador 41650-010, Brazil.
Yan Valdez S RodriguesCentro Universitário SENAI-CIMATEC, Av. Orlando Gomes, 1845, Piatã, Salvador 41650-010, Brazil.
Gabriel de P BuenoResearch Center for Natural and Synthetic Products, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Av. do Café, CEP, 14040-903 Ribeirão Preto, SP, Brazil.
Giuliano C ClososkiResearch Center for Natural and Synthetic Products, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Av. do Café, CEP, 14040-903 Ribeirão Preto, SP, Brazil.
Sandro L BarbosaDepartment of Pharmacy, Universidade Federal dos Vales do Jequitinhonha e Mucuri-UFVJM, Campus JK, Rodovia MGT 367 - Km 583, n° 5.000, Alto da Jacuba, CEP 39100-000 Diamantina, MG, Brazil.ORCID https://orcid.org/0000-0002-0294-5345

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methyl salicylate (MS), the principal constituent of wintergreen oil, was obtained from salicylic acid (SA) by regioselective methylation of the carboxyl group. A new procedure involved exclusive capture of carboxylic hydrogen (-CO

Identifiers

PMID40224406
PMCPMC11983181

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.