ArticleFrontiers in pediatrics2025
Genetic test results and one-year developmental outcomes of fetuses with congenital heart disease.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Spectrum of Copy Number Variants in Fetal Congenital Heart Disease and Their Clinical Implications: A Retrospective Study from a Tertiary Care Center.Diagnostics (Basel, Switzerland) · 2026Article
- Prenatal genetic findings and pregnancy outcomes in fetuses with congenital heart disease: a decade-long retrospective analysis at a tertiary hospital.Frontiers in medicine · 2026Article
- Complementary role of echocardiography, karyotyping, and chromosomal microarray in congenital cardiac anomalies.Frontiers in medicine · 2025Article
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8 authors.
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Abstract
Objective: This study evaluated the utility of single nucleotide polymorphism (SNP) microarray analysis in prenatal genetic assessment of fetuses diagnosed with congenital heart disease (CHD), retrospectively analyzing pregnancy outcomes and their association with physical and intellectual development within the first year of life. Patients and methods: It included 105 fetuses diagnosed with CHD via prenatal echocardiography from January 2016 to June 2020, categorized into two groups: isolated cardiac structural abnormalities (76 cases) and additional extracardiac structural abnormalities (29 cases). All fetuses underwent chromosome karyotype and SNP array testing, with retrospective analysis of pregnancy outcomes, postnatal physical and intellectual development at one year of age. Results: Chromosomal abnormalities were identified in 15.2% (16/105) of the fetuses. A significantly higher incidence of chromosomal abnormalities was observed in the group with combined extra-cardiac structural abnormalities compared to the group with isolated cardiac abnormalities ( Conclusion: SNP array analysis enhances the detection of genetic etiologies in CHD, assisting in the precise localization of chromosomal anomalies and candidate gene screening. It is effective for prenatal diagnosis in CHD fetuses. Fetuses with isolated cardiac structural abnormalities show lower rates of chromosomal anomalies and CNVs and generally have favorable one-year developmental outcomes, underlining the importance of SNP array analysis in managing CHD outcomes.
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