ReviewMedical review (2021)2025
Antimicrobial, remineralization, and infiltration: advanced strategies for interrupting dental caries.
Review in Medical review (2021), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Effectiveness of Topical Fluorides in Preventing Dental Caries in Children and Adolescents: A Systematic Review and Meta-Analysis.Oral health & preventive dentistry · 2026Pooled it
- Effect of intensive application of self-assembling peptide P11-4 with fluoride, casein phosphopeptide amorphous calcium phosphate fluoride and sodium fluoride on streptococcus mutans level in preschool children: a randomized controlled clinical trial.Clinical oral investigations · 2025Trial
- Dental Pulp Stem Cells for the Management of Plaque Biofilm-Associated Infections : A Review.International dental journal · 2026Review
- Enamel Remineralizing Agents: State of the Art.Materials (Basel, Switzerland) · 2026Review
- Evaluating the combined effect of a biomimetic organic matrix and bioinspired fluorapatite nanoparticles on initial caries lesions.RSC advances · 2026Article
- Dental caries beyond eradication: microbiome centered and equilibrium driven therapeutic strategies.Archives of microbiology · 2026Review
- Salivary proteins, proteases, and disease pathophysiology in oral health and precision diagnostics: a narrative review.Frontiers in dental medicine · 2026Review
- Effectiveness of silver diamine fluoride in preventing and arresting dental caries in pediatric dentistry.Dental research journal · 2026Review
- Review
- Biogenic amorphous calcium phosphate: a sustainable alternative for dentin remineralization.BMC oral health · 2025Article
- Polyaspartic Acid-Calcium-Lanthanum Complexes Induce Antibacterial Remineralization of Dentin and In-Depth Occlusion of Dentinal Tubules.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The Oral-Gut Microbiome-Brain Axis in Cognition.Microorganisms · 2025Review
- Formulation and Evaluation of a Licorice-Resveratrol Lollipop for TargetingInfection and drug resistance · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental caries, driven by plaque biofilm, poses a major oral health challenge due to imbalance in mineralization and demineralization. The primary objective in caries management is to maintain biofilm homeostasis while facilitating the repair and regeneration of dental hard tissues, thus restoring both structural integrity and functionality of affected teeth. Though antimicrobial and remineralization approaches haven shown promise, their standalone utilization without concurrent bacterial control or rebalancing lacks an integrated strategy to effectively arrest caries progression. Furthermore, according to the principles of minimally invasive dentistry, treatment materials should exhibit high permeability to ensure optimal sealing of demineralized tooth surfaces. The concept of interrupting dental caries (IDC) has emerged as a holistic approach, drawing upon extensive research encompassing three pivotal techniques: antibacterial strategies, remineralization therapies, and infiltration mechanisms, all of which are indispensable components in combating the progression of dental caries. In this review, we provide a comprehensive overview of the mechanisms and applications of antibacterial, remineralization, and infiltration technologies within the context of caries management. Additionally, we summarize advanced materials that align with the IDC concept, aiming to offer valuable insights for designing next-generation materials adept at preventing or halting caries progression efficiently.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.