Evidence map›Paper›PMID 40224311›Full record

ArticleFrontiers in neurology2025

Examining anterior prefrontal cortex resting-state functional connectivity patterns associated with depressive symptoms in chronic moderate-to-severe traumatic brain injury.

Layan A Elfaki, Bhanu Sharma, Liesel-Ann C Meusel, Isis So, Brenda Colella, Anne L Wheeler, Jocelyn E Harris, Robin E A Green

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Layan A ElfakiTemerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Bhanu SharmaDepartment of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada.
Liesel-Ann C MeuselThe KITE Research Institute, Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada.
Isis SoSchulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Brenda ColellaThe KITE Research Institute, Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada.
Anne L WheelerNeuroscience and Mental Health Program, The Hospital for Sick Children, Toronto, ON, Canada.
Jocelyn E HarrisFaculty of Health Sciences, School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada.
Robin E A GreenThe KITE Research Institute, Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In chronic moderate-to-severe TBI (msTBI), depression is one of the most common psychiatric consequences. Yet to date, there is limited understanding of its neural underpinnings. This study aimed to better understand this gap by examining seed-to-voxel connectivity in depression, with all voxel-wise associations seeded to the bilateral anterior prefrontal cortices (aPFC). In a secondary analysis of 32 patients with chronic msTBI and 17 age-matched controls acquired from the

Indexed as

anterior prefrontal cortexchronic moderate-to-severe traumatic brain injurydepressionfusiform gyruspersonality assessment inventoryseed-based connectivity analysis

Identifiers

PMID40224311
PMCPMC11985445

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.