ArticleAnnals of neurosciences2025
Intracortical Injection of Okadaic Acid Increases Locomotor Activity and Decreases Anxiety-like Behaviour in Adult Male Rats: Potential Involvement of NMDA Receptor.
Article in Annals of neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Neuronal transmission through the Purpose: We attempted to investigate the long-term behavioural effects of Methods: NMDAR was activated by stereotaxic injection of NMDA into the prefrontal cortex of adult rats. To elucidate the role of phosphatases in mediating NMDAR signalling and associated animal behaviour, okadaic acid (OA), a phosphatase inhibitor, was administered before NMDA injection. The animals were tested for their general locomotion and cognitive function using behavioural assays. Results: A single injection of NMDA impaired cognition in the long term. Interestingly, intracortical OA injection resulted in increased locomotor activity and decreased anxiety-like behaviour in animals without major cognitive effects. Conclusion: We demonstrate that the inhibition of phosphatases during NMDAR signalling can affect locomotion and anxiety-like behaviour in adult male rats. Our study underscores the potential of modulating phosphatases as a pharmacological target for anxiety disorders.
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