Evidence map›Paper›PMID 40224275›Full record

ArticleResearch and practice in thrombosis and haemostasis2025

Thiol isomerase ERp18 enhances platelet activation and arterial thrombosis.

Chao He, Aizhen Yang, Keyu Lv, Yuxin Zhang, Zhenzhen Zhao, Yi Lu, Chao Fang, Yue Han, Depei Wu, Miao Jiang and 2 more

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In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chao HeCyrus Tang Medical Institute, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.
Aizhen YangCyrus Tang Medical Institute, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.
Keyu LvDepartment of Pharmacology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Yuxin ZhangDepartment of Hematology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Hematology, Shijiazhuang, China.
Zhenzhen ZhaoCyrus Tang Medical Institute, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.
Yi LuHunan Sinozex Biosciences Co, Ltd, Changsha, China.
Chao FangDepartment of Pharmacology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Yue HanDepartment of Hematology, National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, Institute of Blood and Marrow Transplantation, Soochow University, Suzhou, China.
Depei WuDepartment of Hematology, National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, Institute of Blood and Marrow Transplantation, Soochow University, Suzhou, China.
Miao JiangCyrus Tang Medical Institute, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.
Jingyu ZhangDepartment of Hematology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Hematology, Shijiazhuang, China.
Yi WuCyrus Tang Medical Institute, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Thiol isomerases regulate the thiol-disulfide exchange of functional proteins in cells. Using genetically modified mouse models and inhibitors, we and others demonstrated that 7 thiol isomerases (ERp57, protein diisulfide isomerase, ERp72, ERp46, ERp5, TMX4, and TMX1) participate in thrombosis. There are 21 thiol isomerases in mammals, but whether other enzymes of this family also contribute to thrombosis remains unknown. Objectives: Investigate whether and how ERp18 participates in arterial thrombosis. Methods: ERp18 knockout mice and arterial thrombosis models were used to determine the role of ERp18 in thrombosis. Platelets from ERp18 knockout mice were used to detect aggregation, activation, spreading, and clot retraction. Finally, flow cytometry and immunoprecipitation were used to detect the binding between ERp18 and α Results: The mice lacking ERp18 exhibited a prolonged tail bleeding time and decreased platelet thrombus formation in FeCl Conclusion: ERp18 participates in platelet activation and thrombosis. Its function is, at least in part, through the regulation of integrin α

Indexed as

ERp18integrin αIIbβ3plateletsredox regulationthrombosis

Identifiers

PMID40224275
PMCPMC11986512

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.