Evidence map›Paper›PMID 40224221›Full record

ReviewFrontiers in chemistry2025

Application of Hosomi-Sakurai allylation reaction in total synthesis of biologically active natural products.

Justice Akwensi, Robert T Kumah, Dorcas Osei-Safo, Richard K Amewu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Justice AkwensiDepartment of Chemistry, School of Physical and Mathematical Sciences, College of Basic and Applied Sciences, University of Ghana, Legon, Ghana.
Robert T KumahDepartment of Chemical and Petrochemical Engineering, School of Petroleum Studies, University of Mines and Technology, Tarkwa, Ghana.
Dorcas Osei-SafoDepartment of Chemistry, School of Physical and Mathematical Sciences, College of Basic and Applied Sciences, University of Ghana, Legon, Ghana.
Richard K AmewuDepartment of Chemistry, School of Physical and Mathematical Sciences, College of Basic and Applied Sciences, University of Ghana, Legon, Ghana.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Hosomi-Sakurai allylation reaction has been widely applied in the total synthesis of biologically active natural products, especially in synthesising complex polycyclic compounds containing multi-stereogenic centres since its discovery in 1976. The Hosomi-Sakurai allylation is the allylation of ketones and aldehyde with nucleophilic allylsilanes catalyzed with Lewis acid mainly used to extend the C-C bond in a molecule and also create a new site for manipulation due to the facile transformation of the

Indexed as

carbonylationHosomi-Sakurai allylationlewis acid-promotorsnatural productsstereoselectivitytotal synthesis

Identifiers

PMID40224221
PMCPMC11986726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.