Evidence map›Paper›PMID 40224203›Full record

Trial reportIranian journal of medical sciences2025

The Effectiveness of Modified Mediterranean and Traditional Persian Diets in Fatigue and Depressive Severity in People with Multiple Sclerosis: A Randomized Controlled Clinical Trial.

Mohammad Hossein Sharifi, Maryam Poursadeghfard, Maryam Afshari, Zahra Alizadeh, Mohammad Vatanpour, Mitra Soltani, Hossein Molavi Vardanjani, Amir Mohammad Jaladat, Majid Nimrouzi

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Iranian journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohammad Hossein SharifiResearch Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Maryam PoursadeghfardClinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Maryam AfshariNon-Communicable Diseases Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Zahra AlizadehImam Reza Specialized and Subspecialized Polyclinic, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad VatanpourMaster Student of Nutrition Sciences, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Mitra SoltaniImam Reza Specialized and Subspecialized Polyclinic, Shiraz University of Medical Sciences, Shiraz, Iran.
Hossein Molavi VardanjaniResearch Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Amir Mohammad JaladatResearch Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Majid NimrouziResearch Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Research into managing depression and fatigue, two typical symptoms of multiple sclerosis (MS), is constantly expanding. This study aimed to assess the efficacy of the modified Mediterranean (MED) diet or the Traditional Persian (TP) diet in terms of fatigue and depression severity in patients with MS. Methods: In this single-center, single-blind, randomized clinical trial, 90 patients were enrolled. The patients were randomly assigned to either the MED or TP diet intervention and control groups for two months between July 2022 and February 2023, in Shiraz, Iran. The Krupp Questionnaire for Fatigue Severity Scale and the Beck Depression questionnaire were used. The Chi square test, Kruskal-Wallis test, One-way ANOVA, and backward elimination technique were employed. STATA statistical software (version 17) was utilized for data analysis. P≤0.05 was considered statistically significant. Results: The mean age of 90 participants was 35.64±9.12, and 82.2% were women. The analysis revealed a negative correlation between fatigue severity and MED diet intervention (-4.17 [-8.18-0.16]; P=0.04). However, there was no association between fatigue severity and TP diet intervention (-3.82 [-7.96, 0.32]; P=0.07). The analysis showed that there was a statistically significant relationship between lower depression scores and TP diet intervention (-2.89 [-5.59, -0.19]; P=0.03). However, there was no association between depression scores and MED diet intervention (P=0.22). Lower depression score was also associated with older age and higher socioeconomic status (P=0.002 and P=0.006). It was also shown that longer duration of disease (P=0.05) and higher fatigue severity (P=0.001) were associated with higher depression scores. Conclusion: Adhering to the MED diet could reduce fatigue scores in MS patients while having no effect on the depression score. In contrast, adhering to the TP diet recommendation could reduce depression scores without affecting fatigue scores in MS patients.

Indexed as

DepressionDiet, MediterraneanFatigueMultiple SclerosisAdultFemaleHumansIranMaleMiddle AgedSeverity of Illness IndexSingle-Blind MethodSurveys and QuestionnairesTreatment OutcomeDepressionFatigueMediterranean dietMultiple sclerosisPersian traditional medicine

Identifiers

PMID40224203
PMCPMC11992347

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.