Evidence map›Paper›PMID 40224202›Full record

ArticleIranian journal of medical sciences2025

Comparison between Inhibition of CatSper and KSper Channels with NNC 55-0396 and Quinidine on Human Sperm Function.

Ali Asghar Zarei, Sara Keshtgar, Masoud Haghani, Negar Firouzabadi, Mohammad Hossein Nasr-Esfahani

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ali Asghar ZareiDepartment of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Sara KeshtgarDepartment of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Masoud HaghaniDepartment of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Negar FirouzabadiDepartment of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad Hossein Nasr-EsfahaniDepartment of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Calcium enters human sperm through the "Cation Channel of Sperm" (CatSper), while potassium ions exit via the sperm potassium channel (KSper). These two channels regulate intracellular calcium concentration ([Ca Methods: Results: NNC and quinidine significantly decreased progressive sperm motility (P=0.001) and reduced sperm kinematics (P=0.001). NNC but not quinidine significantly decreased sperm survival (P=0.001), reduced [Ca Conclusion: Inhibition of KSper without effect on [Ca

Indexed as

Calcium ChannelsPotassium ChannelsQuinidineSpermatozoaCalciumHumansMaleSperm MotilityCalciumCalcium ChannelsCATSPER1 protein, humanPotassium ChannelsQuinidineCalcium channelsNNC 55-0396Potassium channelsQuinidine

Identifiers

PMID40224202
PMCPMC11992345

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.