Evidence map›Paper›PMID 40224168›Full record

ArticleTranslational exercise biomedicine2025

Mitochondrial and cardiovascular responses to aerobic exercise training in supine and upright positions in healthy young adults: a randomized parallel arm trial.

Nicholas Preobrazenski, Stuart P S Mladen, Ejaz Causer, Eveline Menezes, Hashim Islam, Patrick J Drouin, Michael E Tschakovsky, Brendon J Gurd

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational exercise biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04151095 (Examining The Effect of Blood Flow Restricted Aerobic Training on Citrate Synthase Activity in Young Healthy Adults), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04151095 nacompletednot on this map

Examining The Effect of Blood Flow Restricted Aerobic Training on Citrate Synthase Activity in Young Healthy Adults

TypeinterventionalSponsorBrendon Gurd, PhDRan2019 to 2019Enrolled19ConditionsMitochondrial BiogenesisArmsBFR Exercise Training, CTL Exercise Training
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicholas PreobrazenskiSchool of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada.ORCID https://orcid.org/0000-0003-1222-221X
Stuart P S MladenSchool of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada.
Ejaz CauserSchool of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada.
Eveline MenezesSchool of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada.
Hashim IslamSchool of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada.
Patrick J DrouinSchool of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada.
Michael E TschakovskySchool of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada.
Brendon J GurdSchool of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Aerobic exercise training can increase skeletal muscle mitochondrial content. Supine exercise training with legs above the heart potentially augments these increases. However, the impact of supine exercise training on mitochondrial biogenesis and cardiovascular adaptations remains unclear. Methods: In this single-centred, randomized, parallel arm trial, 19 recreationally active individuals underwent seven sessions of either supine with legs up (SUP; n=9, 6 females) or upright with legs down (UP; n=10, 7 females) aerobic training on a recumbent bike at 71 ± 7 % and 71 ± 2 % of peak work rate (WR Results: Secondary outcomes revealed significant interaction effects for time to fatigue (TTF) and WR Conclusions: Our exploratory analyses showed that supine aerobic training more effectively improves supine exercise tolerance and performance compared with upright training, despite no differences in measured proteins related to mitochondrial biogenesis. Further research is needed to elucidate the mechanisms underlying these postural-specific training effects. Registration: clinicaltrials.gov: NCT04151095.

Indexed as

aerobic trainingcardiovascular responseexercise performancePGC-1αsupine exercise

Identifiers

PMID40224168
PMCPMC11987498

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.