Evidence map›Paper›PMID 40224148›Full record

ArticleFrontiers in physiology2025

Feasibility and safety of upper limb extremity ergometer exercise in the cardiac intensive care unit in critically ill patients with cardiac disease: a prospective observational study.

Kotaro Hirakawa, Atsuko Nakayama, Takeshi Arimitsu, Kazuki Kon, Hiromichi Ueki, Kentaro Hori, Yuki Ishimoto, Ayaka Ogawa, Ryosuke Higuchi, Yumiko Hosoya and 2 more

Abstract read
In one paragraph

Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kotaro HirakawaDepartment of Rehabilitation, Sakakibara Heart Institute, Tokyo, Japan.
Atsuko NakayamaDepartment of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.
Takeshi ArimitsuDepartment of Rehabilitation, Sakakibara Heart Institute, Tokyo, Japan.
Kazuki KonDepartment of Rehabilitation, Sakakibara Heart Institute, Tokyo, Japan.
Hiromichi UekiDepartment of Rehabilitation, Sakakibara Heart Institute, Tokyo, Japan.
Kentaro HoriDepartment of Rehabilitation, Sakakibara Heart Institute, Tokyo, Japan.
Yuki IshimotoDivision of Nurse, Sakakibara Heart Institute, Tokyo, Japan.
Ayaka OgawaDivision of Nurse, Sakakibara Heart Institute, Tokyo, Japan.
Ryosuke HiguchiDepartment of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.
Yumiko HosoyaDepartment of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.
Mamoru NanasatoDepartment of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.
Mitsuaki IsobeSakakibara Heart Institute, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: There is no established method for early bed rehabilitation of patients after cardiogenic shock (CS) who require mechanical circulatory support (MCS). This study aimed to evaluate the safety of early upper limb extremity ergometer exercise in critically ill patients with CS or at risk for CS. Methods: The study was conducted as a prospective, single-center feasibility and observational study. Patients with CS or at risk for CS in the cardiac intensive care unit were enrolled. Upper limb extremity ergometer exercise was performed with alternating intervals of exercise and rest, in parallel with the rehabilitation program focused on early mobilization. A multidisciplinary team was established to determine the criteria for exercise initiation and cessation. Endpoint measures included exercise-related adverse events (circulatory or respiratory failure requiring new medical intervention, inability to continue device support, bleeding requiring hemostatic treatment at the insertion site, and exercise-related skeletal pain), vital signs, and subjective symptoms. Results: Forty-seven sessions in 28 patients (71 ± 15 years, 75% male) were included in the analysis. MCS was used in 86% of the patients, and rehabilitation was initiated within 3 ± 1 day. Two patients had temporary dyspnea, and none discontinued exercise. There was a significant increase in heart rate (p < 0.05) and respiratory rate (p < 0.001) during exercise compared with pre-excercise, but not in systolic or diastolic blood pressure and oxygen saturation. Conclusion: Early upper limb extremity ergometer exercises for critically ill patients with CS or at risk for CS resulted in changes in heart rate and respiratory rate during exercise. However, no exercise-related adverse events occurred. Upper limb extremity ergometer exercise can be a new tool of physical therapy in the acute phase of patients after CS or at risk for CS.

Indexed as

cardiac diseasecardiac intensive care unitcardiac rehabilitationcardiogenic shockupper limb extremity ergometer

Identifiers

PMID40224148
PMCPMC11985777

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.