ArticleJournal of dental sciences2025
Areca nut extract may be a potentially driving force for tumors to become autophagy addicted.
Article in Journal of dental sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
We have previously described the mechanisms of action and composition of the autophagy-inducing ingredients found in areca nut (AN). These ingredients are 30-100 kDa molecules present in AN extract (ANE), referred to as ANE 30-100K. In other studies, we demonstrated that chronic stimulation with sub-lethal doses of ANE or ANE 30-100K resulted in increased tolerance to environmental challenges, including serum deprivation, hypoxic conditions, anti-cancer drugs, and accelerated tumor growth in nude mice, through upregulated autophagy activity. Such tumor cells were highly sensitive to the chemical inhibition of autophagy both
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