Evidence map›Paper›PMID 40224016›Full record

ArticleiScience2025

Injured tubular epithelia-derived CCN1 promotes the mobilization of fibroblasts toward injury sites after kidney injury.

Tomohiro Nakata, Yuhei Kirita, Minato Umehara, Masashi Nakamura, Shinji Sawai, Atsushi Minamida, Hiroko Yamauchi-Sawada, Yasuto Sunahara, Yayoi Matoba, Natsuko Okuno-Ozeki and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Tomohiro NakataDepartment of Nephrolog, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yuhei KiritaDepartment of Nephrolog, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Minato UmeharaDepartment of Nephrolog, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Masashi NakamuraDepartment of Nephrolog, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Shinji SawaiDepartment of Nephrolog, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Atsushi MinamidaDepartment of Nephrolog, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Hiroko Yamauchi-SawadaDepartment of Nephrolog, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yasuto SunaharaDepartment of Nephrolog, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yayoi MatobaDepartment of Nephrolog, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Natsuko Okuno-OzekiDepartment of Nephrolog, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Itaru NakamuraDepartment of Nephrolog, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Kunihiro NakaiDepartment of Nephrolog, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Aya Yagi-TomitaDepartment of Nephrolog, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Noriyuki YamashitaDepartment of Nephrolog, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Keiichi TamagakiDepartment of Nephrolog, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Benjamin D HumphreysDivision of Nephrology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Satoaki MatobaDepartment of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Tetsuro KusabaDepartment of Nephrolog, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Humoral factors that prompt fibroblasts to migrate to an injury site at an appropriate time point are deemed indispensable for repair after kidney injury. We herein demonstrated the pivotal roles of injured tubule-derived cellular communication network factor 1 (CCN1) in the mobilization of fibroblasts to the injury site after kidney injury. Based on analyses of ligand-receptor interactions

Indexed as

biochemical mechanismbiology of human developmentintegrative aspects of cell biologymolecular interaction

Identifiers

PMID40224016
PMCPMC11987671

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.