Evidence map›Paper›PMID 40223958›Full record

ArticleJournal of thoracic disease2025

Diagnostic value of GeneXpert MTB/RIF in bronchoalveolar lavage fluid for pulmonary non-tuberculosis mycobacterial in acid-fast stain smear-positive and GeneXpert MTB/RIF-negative cases.

Zhengxing Wu, Jichan Shi, Chaochao Qiu, Yueying Zhou, Ning Pan, Lianpeng Wu, Xiangao Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Frontiers in immunology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhengxing WuDepartment of Infection Disease, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, The Second Affiliated Hospital of Shanghai University, Wenzhou, China.
Jichan ShiDepartment of Infection Disease, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, The Second Affiliated Hospital of Shanghai University, Wenzhou, China.
Chaochao QiuDepartment of Infection Disease, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, The Second Affiliated Hospital of Shanghai University, Wenzhou, China.
Yueying ZhouDepartment of Infection Disease, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, The Second Affiliated Hospital of Shanghai University, Wenzhou, China.
Ning PanDepartment of Infection Disease, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, The Second Affiliated Hospital of Shanghai University, Wenzhou, China.
Lianpeng WuDepartment of Laboratory, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, The Second Affiliated Hospital of Shanghai University, Wenzhou, China.
Xiangao JiangDepartment of Infection Disease, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, The Second Affiliated Hospital of Shanghai University, Wenzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The identification of non-tuberculosis (TB) mycobacterial (NTM) infection remains a significant challenge. This study aims to investigate the diagnostic value of multicolour nested real-time fluorescence quantitative nucleic acid amplification detection technology [Xpert Methods: Between 1 January 2017 and 30 June 2022, 365 patients who underwent fibreoptic bronchoscopy and had positive acid-fast smears of BALF were examined using Xpert MTB/RIF. The mycobacteria growth indicator tube (MGIT) 960 was used for rapid sputum culture and traditional drug sensitivity testing. Combined with mycobacterial culture and drug sensitivity results, Xpert results of alveolar lavage fluid were analysed to guide diagnosis and treatment. Results: The sensitivity (Se), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) of Xpert detection for diagnosing NTM lung disease in acid-fast smear-positive cases were 100% (45/45), 99.68% (310/311), 97.83% (45/46) and 100% (310/310), respectively. Conclusions: Xpert MTB/RIF in alveolar lavage fluid can not only detect RIF resistance but also distinguish pulmonary TB from NTM pulmonary disease in patients with positive acid-fast smears.

Indexed as

acid-fast smear-positiveBronchoalveolar lavage fluid (BALF)non-tuberculous mycobacterial lung diseasepulmonary tuberculosis (pulmonary TB)Xpert Mycobacterium tuberculosis/rifampicin (Xpert MTB/RIF)

Identifiers

PMID40223958
PMCPMC11986793

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.