ArticleJournal of thoracic disease2025
Effect of respiratory phase on three-dimensional quantitative parameters of pulmonary subsolid nodules in low-dose computed tomography screening for lung cancer.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Narrative review: the research advances of artificial intelligence in the prediction of pulmonary nodule growth.Journal of thoracic disease · 2026Review
- Clinical analysis of incidental discovery of pulmonary nodules with computed tomography: a retrospective cohort study.Journal of thoracic disease · 2025Article
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Authors and funding
6 authors.
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Abstract
Background: In the screening of pulmonary subsolid nodules (SSNs), it is crucial to compare the quantitative parameters under consistent computed tomography (CT) acquisition conditions, including the same degree of lung inflation. When non-end-inspiratory chest CT scan is performed due to poor breath holding, there is a risk of inaccurate measurement of quantitative parameters and erroneous assessment of pulmonary nodule growth. This study aims to investigate the effect of respiratory phase on three-dimensional (3D) quantitative parameters of SSNs, and to further explore the impact of respiratory phase change on the judgment of SSNs growth during the follow-up of low-dose CT (LDCT) screening. Methods: There were 255 pulmonary SSNs retrospectively found in 230 subjects who received low-dose paired inspiratory and expiratory chest CT screening. Quantitative parameters of lung and SSNs on paired inspiratory and expiratory CT were obtained. The change ratio of expiratory to inspiratory parameters was calculated and labeled as parameter Results: There were statistical differences in all quantitative parameters of lung nodules between the inspiratory CT and the expiratory CT (all P<0.05). The change ratio of long axis diameter of nodules (7.14%) was the smallest, and the change ratio of volume of nodules (20.21%) was the largest. Significant differences were found in the change ratio of most quantitative parameters between part-solid nodules (PSNs) and pure ground-glass nodules (pGGNs). There was no statistical difference in the change ratio of all nodules' parameters between the ≤10 mm group and the >10 mm group (all P>0.05). Nodule density Conclusions: Respiratory phase had the greatest effect on the volume of pulmonary SSNs and the least effect on the long axis diameter. During follow-up, LDCT scan in different respiratory phases may interfere with the judgment of the growth of pulmonary SSNs.
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