Evidence map›Paper›PMID 40223941›Full record

ArticleTremor and other hyperkinetic movements (New York, N.Y.)2025

Lesioning Through a Directional Deep Brain Stimulation Lead in the Subthalamic Nucleus.

Alfonso Enrique Martinez Nunez, Dorian M Kusyk, Joshua K Wong, Michael S Okun, Justin D Hilliard

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Tremor and other hyperkinetic movements (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alfonso Enrique Martinez NunezNorman Fixel Institute for Neurological Disorders, Departments of Neurology and Neurosurgery, University of Florida, Gainesville, FL, US.ORCID 0000-0003-4570-7977
Dorian M KusykNorman Fixel Institute for Neurological Disorders, Departments of Neurology and Neurosurgery, University of Florida, Gainesville, FL, US.ORCID 0000-0003-3750-5160
Joshua K WongNorman Fixel Institute for Neurological Disorders, Departments of Neurology and Neurosurgery, University of Florida, Gainesville, FL, US.ORCID 0000-0002-4632-3417
Michael S OkunNorman Fixel Institute for Neurological Disorders, Departments of Neurology and Neurosurgery, University of Florida, Gainesville, FL, US.ORCID 0000-0002-6247-9358
Justin D HilliardNorman Fixel Institute for Neurological Disorders, Departments of Neurology and Neurosurgery, University of Florida, Gainesville, FL, US.

Funding

Together: Transforming and Translating Discovery to Improve HealthKL2TR001429 · NCATS · UNIVERSITY OF FLORIDA · PI GUIRGIS, FAHEEM W, LEEUWENBURGH, CHRISTIAAN · 2015 to 2023
$5.5M
Web-based Automated Imaging Differentiation of ParkinsonismU01NS119562 · NINDS · UNIVERSITY OF FLORIDA · PI BARMPOUTIS, ANGELOS, OKUN, MICHAEL S · 2021 to 2025
$4.8M
Mobile Decision Support System for Nurse Management of Neuromodulation TherapyR01NR014852 · NINR · UNIVERSITY OF UTAH · PI BUTSON, CHRISTOPHER R, OKUN, MICHAEL S · 2015 to 2019
$2.9M
THE HUMAN THALAMOCORTICAL NETWORK IN TOURETTE SYNDROMER01NS096008 · NINDS · UNIVERSITY OF FLORIDA · PI GUNDUZ, AYSEGUL, OKUN, MICHAEL S · 2016 to 2020
$1.8M
ADVANCING THALAMIC NEUROSTIMULATION FOR SUPPRESING ESSENTIAL VOICE TREMORR01NS131342 · NINDS · UNIVERSITY OF FLORIDA · PI Evangelos A Christou, MICHAEL S OKUN · 2024 to 2026
$1.0M
NIH HHS KL2TR001429NIH HHS R01NS096008NIH HHS R01 NS131342NINDS NIH HHS U01NS119562NINDS NIH HHS UH3NS119844,NINR NIH HHS R01 NR014852
6 · The paper itself

Abstract

Clinical Vignette: A 59-year-old woman with a previous subthalamic nucleus deep brain stimulation (DBS) implanted for Parkinson's disease developed a hardware related infection. Clinical Dilemma: Wound dehiscence and infection developed and necessitated removal of the DBS system. The patient experienced excellent therapeutic benefit from her DBS and expressed concern about device removal. Clinical Solution: The patient was offered the option of a lesioning procedure which could be performed during hardware explantation. An operative procedure was conducted where the intracranial DBS lead was connected to a radiofrequency system in a deliberate effort to create a targeted subthalamotomy through the existing DBS lead. A multilevel lesion was generated using the contacts on the directional DBS lead. Following the lesion the DBS lead and hardware were removed. Gap in Knowledge: Creating a lesion through a DBS lead using radiofrequency ablation is a therapeutic option for patients not interested in later re-implantation or for those with a history of multiple DBS related infections. Lesioning through segmented leads introduces more complexity into the procedure.

Indexed as

Deep Brain StimulationElectrodes, ImplantedParkinson DiseaseSubthalamic NucleusDevice RemovalFemaleHumansMiddle AgedDeep Brain StimulationHardware complicationSubthalamic nucleusSubthalamotomy

Identifiers

PMID40223941
PMCPMC11987846

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.