Evidence map›Paper›PMID 40223932›Full record

ArticleFrontiers in pharmacology2025

Vascular smooth muscle cell-derived SO

Bingquan Qiu, Shangyue Zhang, Shuang Ge, Zhengyu Yu, Deqing Wang, Kun Li, Xiaoqi Yu, Chaoshu Tang, Junbao Du, Hongfang Jin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Lemongrass (Biochemistry research international · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bingquan QiuDepartment of Pediatrics, Children's Medical Center, Peking University First Hospital, Beijing, China.
Shangyue ZhangDepartment of Pediatrics, Children's Medical Center, Peking University First Hospital, Beijing, China.
Shuang GeDepartment of Blood Transfusion Medicine, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Zhengyu YuDepartment of Hematology, West China Hospital, Sichuan University, Chengdu, China.
Deqing WangDepartment of Blood Transfusion Medicine, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Kun LiKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, China.
Xiaoqi YuKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, China.
Chaoshu TangDepartment of Physiology and Pathophysiology, School of Basic Medical Science, Health Science Center, Peking University, Beijing, China.
Junbao DuDepartment of Pediatrics, Children's Medical Center, Peking University First Hospital, Beijing, China.
Hongfang JinDepartment of Pediatrics, Children's Medical Center, Peking University First Hospital, Beijing, China.
Yaqian HuangDepartment of Pediatrics, Children's Medical Center, Peking University First Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Vascular smooth muscle cell (VSMC) senescence is a critical driver of vascular aging and various age-related cardiovascular diseases. Endogenous sulfur dioxide (SO Objective: This study focused on exploring the role of endogenous SO Methods: Aged mice (24 months old), VSMC-specific aspartate aminotransferase 1 (AAT1) knockout (VSMC-AAT1-KO) mice, D-galactose (D-gal)-treated aorta rings and rat VSMC line A7r5 were used in the experiments. AAT1 expression was detected by Western blot and single-cell RNA sequencing. Senescence markers Tp53, p21 Results: The expression of AAT1, a key enzyme for SO Conclusion: Reduction of the endogenous SO

Indexed as

cysteineendogenous SO2IRF1post-translational modificationsulphenylationVSMC senescence

Identifiers

PMID40223932
PMCPMC11986361

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.