ReviewActa informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH2025
Durian and Sapodilla Extracts Enhance Chemotherapy Sensitivity and Promote Apoptosis in Triple Negative Breast Cancer Model in Vitro: Systematic Review.
Review in Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with main option for therapeutic is chemotherapy. Natural compounds, such as durian (Durio zibethinus) and sapodilla (Manilkara zapota) extracts, have demonstrated anticancer properties, including apoptosis induction and the potential to overcome chemotherapy resistance. Objective: This systematic review evaluates the effects of these extracts on TNBC cells, focusing on their ability to enhance chemotherapy sensitivity with induced apoptosis and decreased chemotherapy resistance. Methods: A systematic review was conducted in accordance with PRISMA guidelines. Literature searches in PubMed, Scopus, Web of Science, and Google Scholar identified studies investigating the effects of durian and sapodilla extracts on breast cancer. Data extraction focused on study design, cell lines, preparation and concentrations of extracts, and outcomes such as apoptosis, chemotherapy sensitivity, and molecular marker expression. Results: Included studies demonstrated that durian and sapodilla extracts significantly enhanced the efficacy of chemotherapy agents such as paclitaxel and doxorubicin. Both extracts contained bioactive that reduced Fas, Caspase-3, Caspase-9, and XIAP expression. The combination treatments were shown to synergistically enhance chemotherapy-induced cytotoxicity while reducing resistance mechanisms. Conclusion: Bioactive compounds in durian and sapodilla extracts target multiple pathways involved in TNBC apoptosis, progression and chemotherapy resistance. These findings suggest their potential as natural adjuvants to enhance chemotherapy efficacy. Further studies are needed to validate these results in vivo and explore their clinical applicability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.