ArticleBiotechnology journal2025
Effect of High-Speed Shaking on Oxygen Transfer in Shake Flasks.
Article in Biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- HOM2 and TPK1 are associated with Kluyveromyces marxianus growth under high-temperature and reduced-aeration conditions.World journal of microbiology & biotechnology · 2026Article
- Production of Biosurfactant byInternational journal of molecular sciences · 2026Article
- Reducing the sensitivity of Halomonas sp. to oxygen availability through adaptive laboratory evolution.Microbial cell factories · 2026Article
- A universal medium bridging the shake-flask to fermenter gap inFrontiers in microbiology · 2026Article
- Thermally-driven bacterial mechanism of biogenic amines enrichment in central pile-fermentation zones of Liuyang Douchi.Food chemistry: X · 2025Article
- Bioconversion of a Dairy By-Product (Microorganisms · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shake flasks are predominantly used in screening and the early stages of biotechnological process development. However, oxygen-demanding processes cannot easily be performed in shake flasks, since the maximum oxygen transfer capacity is usually smaller than in stirred reactors. Studies during the last decades suggest that the shaking frequency is one of the most crucial cultivation parameters to sustainably increase oxygen supply in orbitally shaken bioreactors. In this study - for the first time - a prototype of a self-balancing orbital shaker was used, which is capable to be operated at up to 750 rpm shaking frequency at 25 mm shaking diameter and 600 rpm at 50 mm. Kluyveromyces lactis cultivations were monitored with a modified TOM system to measure the maximum oxygen transfer capacities (OTR
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.