Evidence map›Paper›PMID 40223659›Full record

ArticleArthritis care & research2025

Understanding Contributors of Resilience in Youth With Childhood-Onset Systemic Lupus Erythematosus Through a Socioecological Lens: A Mixed-Methods Study.

Isabella Zaffino, Louise Boulard, Joanna Law, Asha Jeyanathan, Lawrence Ng, Sandra Williams-Reid, Kiah Reid, Angela Cortes, Eugene Cortes, Ashley Danguecan and 3 more

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In one paragraph

Article in Arthritis care & research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Isabella ZaffinoSickKids Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0001-7857-9268
Louise BoulardSickKids Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
Joanna LawSickKids Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
Asha JeyanathanSickKids Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
Lawrence NgSickKids Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
Sandra Williams-ReidThe Hospital for Sick Children, Toronto, Ontario, Canada.
Kiah ReidThe Hospital for Sick Children, Toronto, Ontario, Canada.
Angela CortesThe Hospital for Sick Children, Toronto, Ontario, Canada.
Eugene CortesThe Hospital for Sick Children, Toronto, Ontario, Canada.
Ashley DanguecanThe Hospital for Sick Children, Toronto, Ontario, Canada.
Deborah M LevySickKids Research Institute, The Hospital for Sick Children, and University of Toronto, Toronto, Ontario, Canada.
Linda T HirakiSickKids Research Institute, The Hospital for Sick Children, and University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-6690-8148
Andrea M KnightThe Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-4278-9049

Funding

Canadian Institutes for Health Research - Canada Research Chair Tier 2 in Mental Health and Chronic Disease of ChildhoodLupus Research AllianceSickKids Garry Hurvitz Centre for Brain and Mental Health OutcomesU.S. Department of Defense
6 · The paper itself

Abstract

objectiveThis study aimed to identify themes contributing to resilience in childhood-onset systemic lupus erythematosus (cSLE), distinguish between profiles of resilience, and examine how they relate to underlying themes and patient characteristics.

methodsWe conducted a mixed-methods study of 21 patients with cSLE aged 11 to 19 years at a Canadian tertiary care center from October 2022 to July 2024. We purposively sampled patients belonging to ethnically and culturally diverse backgrounds to complete semistructured interviews. We qualitatively defined features of resilience and distinguished profiles of low versus high socioecological resilience according to patient median on the Child and Youth Resilience Measure-Revised (CYRM-R). Profiles were then related to sociodemographic (eg, adverse childhood experiences, health literacy), disease features (eg, age at diagnosis, disease duration), and patient-reported outcomes (eg, anxiety and depressive symptoms).

resultsFactors contributing to resilience were grouped into five themes: familial environment, social support beyond family, health services and information, life with SLE, and sense of self. Cultural influences were reported to impact several themes. Patients with high resilience (scores above 73 on CYRM-R) reported more facilitators in each thematic area, whereas patients with low resilience experienced more challenges in these areas, in addition to greater number of adverse childhood experiences, lower health literacy, earlier age at diagnosis, longer disease duration and poorer mental health.

conclusionFindings support a dynamic model of resilience, shaped by a combination of sociodemographic, disease, personal, cultural and social factors. This improved understanding of resilience may help direct comprehensive care for youth with cSLE and guide targeted interventions for youth at risk of poor outcomes.

Indexed as

Lupus Erythematosus, SystemicResilience, PsychologicalAdolescentAge of OnsetCanadaChildFemaleHumansMaleSocial SupportYoung Adult

Identifiers

PMID40223659
PMCPMC12371310

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.