Evidence map›Paper›PMID 40223610›Full record

ReviewCirculation. Heart failure2025

Gaps and Knowledge in the Contemporary Management of Acute Right Ventricular Failure.

Paolo Manca, Vincenzo Nuzzi, Massimiliano Mulè, Sergio Sciacca, Matteo Castrichini, Uwe Schulz, Naveen L Pereira, Holger Thiele, Jacob C Jentzer, Manlio Cipriani

Abstract readReview
In one paragraph

Review in Circulation. Heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Bridging the Gap: Exploring Right Ventricular-Pulmonary Artery Coupling in Acute Coronary syndrome-A Pilot Study.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Paolo MancaClinical Cardiology and Heart Failure Department, IRCCS-ISMETT (Mediterranean Institute for Transplantation and Advanced Specialized Therapies), Palermo, Italy (P.M., V.N., M.M., M. Cipriani). Cardiac Surgery, IRCCS-ISMETT (Mediterranean Institute for Transplantation and Advanced Specialized Therapies), Palermo, Italy.ORCID 0000-0003-3383-9657
Vincenzo NuzziClinical Cardiology and Heart Failure Department, IRCCS-ISMETT (Mediterranean Institute for Transplantation and Advanced Specialized Therapies), Palermo, Italy (P.M., V.N., M.M., M. Cipriani). Cardiac Surgery, IRCCS-ISMETT (Mediterranean Institute for Transplantation and Advanced Specialized Therapies), Palermo, Italy.
Massimiliano MulèClinical Cardiology and Heart Failure Department, IRCCS-ISMETT (Mediterranean Institute for Transplantation and Advanced Specialized Therapies), Palermo, Italy (P.M., V.N., M.M., M. Cipriani). Cardiac Surgery, IRCCS-ISMETT (Mediterranean Institute for Transplantation and Advanced Specialized Therapies), Palermo, Italy.ORCID 0000-0001-6244-4473
Sergio Sciacca
Matteo CastrichiniDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (M. Castrichini, N.L.P., J.C.J.).ORCID 0000-0002-2405-3364
Uwe SchulzUniversity Department of Cardiac Surgery, Leipzig Heart Center, Germany (U.S.).
Naveen L PereiraDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (M. Castrichini, N.L.P., J.C.J.).ORCID 0000-0003-3813-3469
Holger ThieleHeart Center Leipzig at Leipzig University, Department of Internal Medicine/Cardiology, Germany (H.T.).ORCID 0000-0002-0169-998X
Jacob C JentzerDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (M. Castrichini, N.L.P., J.C.J.).ORCID 0000-0002-6366-2859
Manlio CiprianiClinical Cardiology and Heart Failure Department, IRCCS-ISMETT (Mediterranean Institute for Transplantation and Advanced Specialized Therapies), Palermo, Italy (P.M., V.N., M.M., M. Cipriani). Cardiac Surgery, IRCCS-ISMETT (Mediterranean Institute for Transplantation and Advanced Specialized Therapies), Palermo, Italy.ORCID 0000-0002-0632-0561

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute right ventricular failure (ARVF) is commonly seen in the intensive care unit and constitutes a significant clinical challenge, with associated high in-hospital mortality. Recently, the treatment of ARVF has significantly changed, with the progressive implementation of mechanical circulatory support devices that now represent important tools for clinicians in treating this condition. However, despite recent advancements, the optimal approach for ARVF remains elusive, and precise treatment algorithms and comprehensive management protocols are still lacking. In the present review, we explore the pathophysiology of ARVF, highlighting the different mechanisms that may lead to this clinical entity and emphasizing the left and right heart's complex interplay. We analyze the different therapeutic options that are now available for short- and long-term management of ARVF, with a particular focus on the advantages and disadvantages of the mechanical circulatory support devices actually used. Furthermore, we propose future directions in the field and a possible flowchart for the treatment of this condition.

Indexed as

Heart FailureVentricular Dysfunction, RightVentricular Function, RightAcute DiseaseHeart-Assist DevicesHumansTreatment Outcomeheartheart failurehospital mortalityintensive care unitssoftware design

Identifiers

PMID40223610
PMCPMC12435249

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.