Evidence map›Paper›PMID 40223598›Full record

ArticleEuropean journal of immunology2025

Rapid Detection of Anti-IFN-α2 Autoantibodies Using a New Automated VIDAS Assay Prototype.

Sylvie Pons, Laurence Generenaz, Adrian Gervais, Anne Puel, Paul Bastard, Nathalie Renard, Valerie Guyot, Cecile Vinit, Fei Zheng, Karen Brengel-Pesce and 9 more

Abstract read
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. High risk of hypoxemic COVID-19 pneumonia in myasthenia gravis patients with type I IFN autoantibodies.Proceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Sylvie PonsJoint Research Unit Civils Hospices of Lyon-bioMérieux, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France.ORCID 0000-0002-6286-0546
Laurence GenerenazJoint Research Unit Civils Hospices of Lyon-bioMérieux, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France.
Adrian GervaisSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York, USA.ORCID 0000-0002-1083-5787
Anne PuelSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York, USA.
Paul BastardSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York, USA.
Nathalie RenardR&D Department of Immunoassays, bioMérieux S.A., Marcy l'Etoile, France.ORCID 0000-0002-0402-1111
Valerie GuyotR&D Department of Immunoassays, bioMérieux S.A., Marcy l'Etoile, France.
Cecile VinitR&D Department of Immunoassays, bioMérieux S.A., Marcy l'Etoile, France.
Fei ZhengJoint Research Unit Civils Hospices of Lyon-bioMérieux, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France.
Karen Brengel-PesceJoint Research Unit Civils Hospices of Lyon-bioMérieux, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France.
Kahina SakerJoint Research Unit Civils Hospices of Lyon-bioMérieux, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France.
Jean-Christophe RichardIntensive Care Unit, Croix-Rousse Hospital, Hospices Civils de Lyon, Lyon, France.
Alexis MathianAssistance Publique-Hôpitaux de Paris, Sorbonne Université, Groupement Hospitalier Pitié-Salpêtrière, French National Referral Center for Systemic Lupus Erythematosus, Antiphospholipid Antibody Syndrome and Other Autoimmune Disorders, Service de Médecine Interne 2, Institut E3M, Inserm UMRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.
Zahir AmouraAssistance Publique-Hôpitaux de Paris, Sorbonne Université, Groupement Hospitalier Pitié-Salpêtrière, French National Referral Center for Systemic Lupus Erythematosus, Antiphospholipid Antibody Syndrome and Other Autoimmune Disorders, Service de Médecine Interne 2, Institut E3M, Inserm UMRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.
Karim DorghamSorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.
Guy GorochovSorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.
Jean-Laurent CasanovaSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York, USA.
Aurore FleurieJoint Research Unit Civils Hospices of Lyon-bioMérieux, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France.
Sophie Trouillet-AssantJoint Research Unit Civils Hospices of Lyon-bioMérieux, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France.

Funding

ANR-RHU COVIFERON Program ANR-21-RHUS-08French Foundation for Medical Research (EA20170638020)French Foundation for Medical Research FRMEQU202203014622HORIZON-HLTH-2021-DISEASE-04 program 101057100)HORIZON-HLTH-2021-DISEASE-04 program (UNDINEInstitut National de la Santé et de la Recherche Médicale (INSERM)MD-PhD program of the Imagine Institute (SupportoftheFondationBettencourt-Schueller)"Poste CCA-INSERM-Bettencourt" (SupportoftheFondationBettencourt-Schueller)Sorbonne Université
6 · The paper itself

Abstract

Autoantibodies neutralizing Type I interferons increase the risk of severe viral diseases and are linked to autoimmune conditions. The automated VIDAS assay is suitable for anti-IFN-α2 IgGs quantification, offering a swift, reliable, user-friendly, single test for clinical management.

Indexed as

AutoantibodiesInterferon-alphaAutoimmune DiseasesHumansImmunoassayImmunoglobulin GAutoantibodiesImmunoglobulin GInterferon-alphaautoantibodiesclinical applicationsingle‐sample testtype I interferonsVIDAS

Identifiers

PMID40223598
PMCPMC11995241

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.