Evidence map›Paper›PMID 40223491›Full record

ArticleHistology and histopathology2025

PlGF/Flt-1/MMP-1 axis in gingival carcinoma bone invasion.

Phuong Thao Nguyen, Mutsumi Miyauchi, Ajiravudh Subarnbhesaj, Ikuko Ogawa, Chanbora Chea, Takashi Takata

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Article in Histology and histopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Phuong Thao NguyenDepartment of Molecular Oral Pathology and Oncology, Graduate School of Medical and Dental Science, Kagoshima University, Japan. ntpthao@dent.kagoshima-u.ac.jp.
Mutsumi MiyauchiDepartment of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical and Health Science, Hiroshima University, Japan.
Ajiravudh SubarnbhesajDepartment of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical and Health Science, Hiroshima University, Japan.
Ikuko OgawaDepartment of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical and Health Science, Hiroshima University, Japan.
Chanbora CheaDepartment of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical and Health Science, Hiroshima University, Japan.
Takashi TakataDepartment of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical and Health Science, Hiroshima University, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGingival squamous cell carcinoma (SCC) frequently invades adjacent bone tissue, leading to significant morbidity and mortality. Understanding the molecular mechanisms driving bone invasion is crucial for developing targeted therapies. We investigated the role of placental growth factor (PlGF) in this process, focusing on its interaction with RANKL and MMP-1.

methodsWe examined the role of PlGF in bone invasion of gingival SCC through analysis of patient samples (n=55) and various

resultsOur findings demonstrate that gingival SCC-secreted PlGF promotes local bone invasion through two possible ways: 1) direct induction of RANKL expression, activating osteoclast formation and bone resorption, and 2) indirect upregulation of RANKL via MMP-1 signaling. PlGF secretion by tumor cells triggered RANKL and MMP-1 production and significantly stimulated migration and osteoclastogenesis (

conclusionThis study identifies PlGF as a key regulator of osteoclastogenesis in gingival SCC through both direct and MMP-1-mediated pathways. Therefore, targeting PlGF activity may represent a potential therapeutic strategy for inhibiting bone invasion in gingival SCC.

Indexed as

Bone NeoplasmsCarcinoma, Squamous CellGingival NeoplasmsMatrix Metalloproteinase 1Placenta Growth FactorVascular Endothelial Growth Factor Receptor-1AgedCell Line, TumorCell MovementFemaleHumansMaleMiddle AgedNeoplasm InvasivenessOsteoclastsRANK LigandFLT1 protein, humanMatrix Metalloproteinase 1MMP1 protein, humanPGF protein, humanPlacenta Growth FactorRANK LigandTNFSF11 protein, humanVascular Endothelial Growth Factor Receptor-1

Identifiers

PMID40223491

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.