Evidence map›Paper›PMID 40223372›Full record

ArticlePhysiological reports2025

Absolute substrate oxidation rates are lower in older adults with amnestic mild cognitive impairment.

Nicholas A Rizzi, Mary K Kramer, Theodore M DeConne, James M Ellison, Alyssa M Lanzi, Matthew L Overstreet, David G Edwards, Matthew L Cohen, Curtis L Johnson, Christopher R Martens

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicholas A RizziDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA.
Mary K KramerDepartment of Biomedical Engineering, University of Delaware, Newark, Delaware, USA.ORCID 0000-0003-1305-9821
Theodore M DeConneDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA.
James M EllisonDepartment of Psychiatry and Human Behavior, Jefferson Health, Philadelphia, Pennsylvania, USA.
Alyssa M LanziDepartment of Communication Sciences and Disorders, University of Delaware, Newark, Delaware, USA.
Matthew L OverstreetDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA.
David G EdwardsDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA.
Matthew L CohenDepartment of Communication Sciences and Disorders, University of Delaware, Newark, Delaware, USA.
Curtis L JohnsonDepartment of Biomedical Engineering, University of Delaware, Newark, Delaware, USA.
Christopher R MartensDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA.ORCID 0000-0003-0578-2948

Funding

Vascular Consequences of Duchenne Muscular DystrophyP20GM113125 · NIGMS · UNIVERSITY OF DELAWARE · PI LENNON, SHANNON L. · 2016 to 2025
$23.3M
Mechanical integrity of memory systems in mild cognitive impairmentR01AG058853 · NIA · UNIVERSITY OF DELAWARE · PI JOHNSON, CURTIS L · 2018 to 2022
$2.3M
NAD+ Therapy for Improving Memory & Cerebrovasular Function in Patients with MCIK01AG054731 · NIA · UNIVERSITY OF DELAWARE · PI MARTENS, CHRISTOPHER · 2017 to 2021
$723k
HHS | National Institutes of Health (NIH) P20GM113125Howard W. Swank, Alma K. Swank, and Richard Kemper Swank Foundation n/aNIA NIH HHS K01 AG054731NIA NIH HHS R01 AG058853NIGMS NIH HHS P20 GM113125
6 · The paper itself

Abstract

Previous studies in individuals with mild cognitive impairment suggest that they may have altered systemic metabolic function at rest; however, metabolic function during aerobic exercise is not fully understood in this population. This study sought to determine whether individuals with amnestic mild cognitive impairment (aMCI) have lower rates of baseline and peak fat oxidation (FatOx) during a graded exercise test (GXT) compared with cognitively unimpaired control participants (CU). Twenty-two (22) older adults with aMCI and 21 age- and sex-matched adults completed a GXT to assess rates of substrate oxidation and peak oxygen consumption (VO

Indexed as

AmnesiaCognitive DysfunctionAgedCarbohydrate MetabolismExerciseExercise TestFemaleHumansMaleOxidation-ReductionOxygen Consumptionamnestic mild cognitive impairmentexercisesubstrate oxidation

Identifiers

PMID40223372
PMCPMC11994860

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.