ArticleBMC oral health2025
Sulfonated polyether ketone ketone (SPEKK) implant as an alternative to titanium implant-in vivo study on Wistar Albino rat mandible.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Biomimetic Surface Engineering Strategies for Enhanced Osseointegration and Peri-Implant Bone Regeneration: A Systematic Review.Biomimetics (Basel, Switzerland) · 2026Review
- Material-dependent trueness of intraoral scanners: A comparative analysis of three scanning technologies for different crowns - An in vitro study.Journal of Indian Prosthodontic Society · 2026Article
- Comparison of dimensional accuracy between two commercially available light-activated and chemically activated acrylic resins for verification jigs in implant prosthodontics: An in vitro study.Journal of Indian Prosthodontic Society · 2026Article
- Finite Element Analysis of Implant-Assisted Mandibular Distal Extension Removable Partial Denture: Evaluating Stress Distribution in Premolar Versus Molar Implant Positions-An In-Silico Study.Health science reports · 2025Article
- Assessing the role of PEKK implant material on cytotoxicity, inflammatory response, and molecular interactions with pro-inflammatory cytokines: An in-vitro and in-silico study.Journal of oral biology and craniofacial researchArticle
- Stress evaluation of different cad-on material combinations in crown design over conventional hand-layered zirconia - an in vitro 3d finite element analysis.Revista cientifica odontologica (Universidad Cientifica del Sur)Article
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Authors and funding
6 authors.
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Abstract
backgroundTitanium is commonly used for dental implants due to its high biocompatibility and durability. However, concerns about metal ion release and aesthetic limitations in certain tissue biotypes have driven the search for alternative materials. Polyetherketoneketone (PEKK), a high-performance polymer, has emerged as a promising option due to its biomimetic properties. Surface modifications, such as treatment with sulfuric acid (H2SO4), may further enhance its osteogenic potential.
aimThe study aimed to evaluate the osteogenic efficacy of H2SO4-modified PEKK implants in comparison to titanium implants. METHODOLOGY: Three groups were assessed: Titanium, unmodified PEKK and H2SO4-modified PEKK(SPEKK). Surface characteristics were analyzed using scanning electron microscopy (SEM). Wettability was checked through contact angle evaluation. Cell viability was evaluated through MTT assays. Implants were placed in rat mandibles, and bone formation was analyzed after 6 weeks using nano-CT and histological assessments. Toxicity was as Statistical comparisons were performed using one-way ANOVA and Tukey's post-hoc test.
resultsAcid-modified PEKK implants exhibited the highest bone formation (280.09 ± 12.03) significantly outperforming Titanium (265.12 ± 11.08) and unmodified PEKK (266.52 ± 7.28) (p < 0.05).
conclusionsH2SO4-modified PEKK (SPEKK) implants demonstrated superior osteogenic properties compared to titanium, suggesting that these modified polymers could be viable alternatives for aesthetic implants.
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