ArticleScientific reports2025
Genome-wide identification of the TGF-β superfamily and their expression in the Chinese mitten crab Eriocheir sinensis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Effects of All-Trans Retinoic Acid on Ovarian Development, Lipid Metabolism, Nutritional Quality, and Gut Microbiota of Female Chinese Mitten Crab During Fattening Period.International journal of molecular sciences · 2026Article
- The Papilla Stage as a Critical Molecular Transition:Animals : an open access journal from MDPI · 2026Article
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5 authors.
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Abstract
Transforming growth factor-β superfamily genes are multifunctional cytokines that play central roles in the regulation of cell proliferation, differentiation, apoptosis, adhesion, and migration. Identifying the TGF-β superfamily in crabs could provide a basis for elucidating the genetic regulatory mechanism of growth, development, sex differentiation and environmental adaptation. To understand the complexity and evolution of the TGF-β superfamily in the Chinese mitten crab Eriocheir sinensis, this study comprehensively and systematically analysed this superfamily in the genome of E. sinensis. A total of 9 TGF-β superfamily genes have been identified, including EsBMP2, EsBMP3, EsBMP7, EsBMP10, EsBMP15, EsGDF8, EsUnivin, EsINHB and EsINHBB. A wide variation in the number of motifs and CDSs was found among different subfamilies. The expression of EsBMP2 and EsBMP7 suggested that these genes may be the main genes controlling embryonic development in E. sinensis. EsBMP2, EsBMP7 and EsBMP10 are very highly expressed in the gills. The TGF-β superfamily genes presented different expression patterns during limb regeneration and molting. In addition, this gene family also responds to environmental stresses, including nanoplastic stress, cadmium stress, air exposure, and high-salinity stress, which provides a new perspective for understanding the strong tolerance and adaptability of crabs to environmental stress. To our knowledge, this study is the first genome-wide investigation of the TGF-β superfamily in crabs. This study identified the sequence structure, phylogenetic relationship, and gene expression profiles of the TGF-β superfamily genes in the Chinese mitten crab, and the above results lay a foundation for further investigation of the evolution and biological functions of this gene family.
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