Evidence map›Paper›PMID 40222952›Full record

ArticlePharmacology research & perspectives2025

β-Adrenergic Blockers Increase cAMP and Stimulate Insulin Secretion Through a PKA/RYR2/TRPM5 Pathway in Pancreatic β-Cells In Vitro.

Naoya Murao, Risa Morikawa, Yusuke Seino, Kenju Shimomura, Yuko Maejima, Yuichiro Yamada, Atsushi Suzuki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology research & perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Old Drugs, New Opportunities: Advancing Cancer Care Through Repurposing.United European gastroenterology journal · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Naoya MuraoDepartment of Endocrinology, School of Medicine, Diabetes and Metabolism, Fujita Health University, Toyoake, Japan.ORCID 0000-0002-7424-4476
Risa MorikawaDepartment of Endocrinology, School of Medicine, Diabetes and Metabolism, Fujita Health University, Toyoake, Japan.
Yusuke SeinoDepartment of Endocrinology, School of Medicine, Diabetes and Metabolism, Fujita Health University, Toyoake, Japan.
Kenju ShimomuraDepartment of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan.
Yuko MaejimaDepartment of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan.
Yuichiro YamadaDepartment of Endocrinology, School of Medicine, Diabetes and Metabolism, Fujita Health University, Toyoake, Japan.
Atsushi SuzukiDepartment of Endocrinology, School of Medicine, Diabetes and Metabolism, Fujita Health University, Toyoake, Japan.

Funding

Daiwa Securities Health FoundationFujita Health UniversityHori Sciences and Arts FoundationJapan Association for Diabetes Education and CareJapan Diabetes FoundationJapan Society for the Promotion of Science JP22K20869Japan Society for the Promotion of Science JP23K15401Manpei Suzuki Diabetes FoundationSuzuken Memorial Foundation
6 · The paper itself

Abstract

β-adrenergic blockers (β-blockers) are extensively used to inhibit β-adrenoceptor activation and subsequent cAMP production in many cell types. In this study, we characterized the effects of β-blockers on mouse pancreatic β-cells. Unexpectedly, high concentrations (100 μM) of β-blockers (propranolol and bisoprolol) paradoxically increased cAMP levels 5-10 fold, enhanced Ca

Indexed as

Adrenergic beta-AntagonistsCyclic AMPInsulin-Secreting CellsInsulin SecretionAnimalsBisoprololCalciumCyclic AMP-Dependent Protein KinasesGlucoseInsulinMaleMiceMice, Inbred C57BLPhosphorylationPropranololRyanodine Receptor Calcium Release ChannelAdrenergic beta-AntagonistsBisoprololCalciumCyclic AMPCyclic AMP-Dependent Protein KinasesGlucoseInsulinPropranololRyanodine Receptor Calcium Release ChannelTRPM Cation Channels

Identifiers

PMID40222952
PMCPMC11994265

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.