ArticleInternal medicine (Tokyo, Japan)2025
Obinutuzumab-induced Acute Thrombocytopenia Mimicking Immune Thrombocytopenia in a Patient with Follicular Lymphoma.
Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Reconsidering the Diagnosis and Management of Obinutuzumab-induced Acute Thrombocytopenia.Internal medicine (Tokyo, Japan) · 2026Article
- Immune-mediated acute thrombocytopenia within 30 minutes of first obinutuzumab infusion.Blood vessels, thrombosis & hemostasis · 2026Article
- Obinutuzumab-induced acute thrombocytopenia and leukopenia in ANCA-associated glomerulonephritis: case report and literature review.Frontiers in immunology · 2026Review
- Acute obinutuzumab-induced thrombocytopenia in follicular lymphoma: case report and literature review.Frontiers in oncology · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
Obinutuzumab-induced acute thrombocytopenia is characterized by a rapid decrease in the platelet count after administration. The underlying mechanisms remain unclear. However, we present novel laboratory findings related to its pathophysiology. A 65-year-old woman with follicular lymphoma developed acute thrombocytopenia within 24 hours after obinutuzumab administration. Laboratory results showed features resembling acute immune thrombocytopenic purpura, including an elevated immature platelet fraction, mildly increased thrombopoietin levels, elevated platelet-associated immunoglobulin G, and refractory to platelet transfusion. Our case and her laboratory findings suggest that increased platelet consumption might be involved in the development of obinutuzumab-induced acute thrombocytopenia.
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Registered trials
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