Evidence map›Paper›PMID 40222917›Full record

ArticleAnnals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia2025

Clinical Outcomes of Catheter-Directed Thrombolysis versus Mechanical Aspiration in Patients with Acute Pulmonary Embolism.

Zhe Zhang, Shanshan Jin, Bin Liu, Hai Feng, Wenrui Li

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Zhe ZhangDepartment of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Shanshan JinDepartment of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Bin LiuDepartment of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Hai FengDepartment of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Wenrui LiDepartment of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe objective of this study was to evaluate the safety and efficacy of catheter-directed thrombolysis (CDT) and mechanical aspiration (MA) for acute pulmonary embolism (PE).

methodsFrom February 2022 to October 2024, the clinical data of patients with high- and intermediate-risk PE who received endovascular therapy were retrospectively reviewed. Patients were categorized based on the treatment strategy.

resultsFifty-eight consecutive patients were identified. CDT was initiated in 29 patients, while the remaining 29 received MA treatment. The time of thrombolysis and the dosage of urokinase were both lower in the MA group (P <0.05). No differences were found in cardiac biomarkers after 48 hours, perioperative bleeding events, heart/valve injury, and mortality. The total cost of the MA group was much higher compared to CDT alone. The MA group showed better improvement in right ventricular (RV) function with a higher reduction in the right ventricular-to-left ventricular ratio (0.55 ± 0.46 vs. 0.13 ± 0.53, P = 0.017). No differences were found in the reduction of the CT obstruction index.

conclusionCDT and MA seem to have similar outcomes for patients with acute high- and intermediate-risk PE. MA is more effective in improving RV function with less thrombolysis time and fewer thrombolytics.

Indexed as

Fibrinolytic AgentsPulmonary EmbolismThrombectomyThrombolytic TherapyAcute DiseaseAgedFemaleHumansMaleMiddle AgedRecovery of FunctionRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeUrokinase-Type Plasminogen ActivatorFibrinolytic AgentsUrokinase-Type Plasminogen Activatoracute pulmonary embolismaspiration thrombectomycatheter thrombolysissuction thrombectomy

Identifiers

PMID40222917
PMCPMC12009743

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