Evidence map›Paper›PMID 40222816›Full record

Observational studyESC heart failure2025

A multicentre registry of hospitalized patients with acute and chronic heart failure: Study design of the H

Johannes Leiner, Sebastian König, Anne Nitsche, Sven Hohenstein, Jana Nagel, Melchior Seyfarth, Henning Baberg, Alexander Lauten, Hans Neuser, Alexander Staudt and 6 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in ESC heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04844944 (The Helios Heart Registry), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04844944 recruitingnot on this map

The Helios Heart Registry: A Standardized Registry for Capturing Clinical and Patient-reported Outcomes in Patients With Specific Cardiac Diseases: Application of the ICHOM Standard in Clinical Practice

Typeobservational_patient_registrySponsorHelios Health Institute GmbHRan2021 to 2026Enrolled24,000ConditionsHeart Failure, Coronary Artery Disease, Atrial Fibrillation
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Sex-specific differences in disease severity and outcomes in left ventricular heart failure: a nationwide cohort study.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Johannes LeinerDepartment of Electrophysiology, Heart Centre Leipzig at University of Leipzig, Leipzig, Germany.
Sebastian KönigDepartment of Electrophysiology, Heart Centre Leipzig at University of Leipzig, Leipzig, Germany.
Anne NitscheReal World Evidence and Health Technology Assessment at the Helios Health Institute, Berlin, Germany.
Sven HohensteinReal World Evidence and Health Technology Assessment at the Helios Health Institute, Berlin, Germany.
Jana NagelStudy Centre Leipzig at the Helios Health Institute, Leipzig, Germany.
Melchior SeyfarthDepartment of Cardiology, University Hospital Wuppertal, University of Witten/Herdecke, Wuppertal, Germany.
Henning BabergDepartment of Cardiology and Nephrology, Helios Hospital Berlin-Buch, Berlin, Germany.
Alexander LautenDepartment of Cardiology, Helios Hospital Erfurt, Erfurt, Germany.
Hans NeuserDepartment of Cardiology and Angiology, Helios Hospital Plauen, Plauen, Germany.
Alexander StaudtDepartment of Cardiology and Angiology, Helios Hospital Schwerin, Schwerin, Germany.
Jürgen TebbenjohannsDepartment of Cardiology and Intensive Care, Helios Hospital Hildesheim, Hildesheim, Germany.
René AndriéDepartment of Cardiology, Rhythmology and Electrophysiology, Helios Hospital Siegburg, Siegburg, Germany.
Michael NiehausDepartment of Cardiology, Helios Hospital Gifhorn, Gifhorn, Germany.
Markus W FerrariClinic for Internal Medicine I: Cardiology and Intensive Care, Helios Dr. Horst Schmidt Hospital Wiesbaden, Wiesbaden, Germany.
Ralf KuhlenHelios Health Institute GmbH, Berlin, Germany.
Andreas BollmannDepartment of Electrophysiology, Heart Centre Leipzig at University of Leipzig, Leipzig, Germany.

Funding

AstraZeneca GmbH
6 · The paper itself

Abstract

aimsHeart failure (HF) is a highly prevalent condition affecting 1-3% of the adult population in Europe. Despite landmark improvements in HF care over the last two decades, hospitalization and mortality rates remain relatively high. Gathering real-world data on HF populations is crucial, especially in the light of newly emerging therapeutic approaches. The Helios Heart (H METHODS AND

resultsThe H

conclusionsThe H TRIAL REGISTRATION NUMBER: NCT04844944.

Indexed as

Heart FailureHospitalizationRegistriesAcute DiseaseAgedChronic DiseaseFemaleFollow-Up StudiesGermanyHumansMaleMiddle AgedProspective StudiesAcute heart failureChronic heart failureGuideline‐directed medical therapyHospitalizationMortalityPatient registryPatient‐reported outcomes

Identifiers

PMID40222816
PMCPMC12287812

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.