ArticleDevelopmental biology2025
PCP-dependent polarized mechanics in the cortex of individual cells during convergent extension.
Article in Developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Mathematical modeling of planar cell polarity: principles, approaches, and open questions.NPJ systems biology and applications · 2026Review
- StrainMapperJ: An Easy-to-Use Digital Image Correlation Toolkit for Exploring and Quantifying the Mechanics of Deforming Tissues.Results and problems in cell differentiation · 2026Article
- Strained actin binding by the Prickle2 LIM domains and their regulation in the full-length protein.Molecular biology of the cell · 2026Article
- Linking Planar Cell Polarity to Mechanotransduction During Morphogenesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Mechanosensitive localization of Diversin highlights its function in vertebrate morphogenesis and planar cell polarity.Biology open · 2025Article
- Planar polarized force propagation integrates cell behavior with tissue shaping during convergent extension.Current biology : CB · 2025Article
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5 authors.
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Abstract
Convergent extension (CE) is a key process for tissue elongation during vertebrate development and is driven by polarized cell behaviors. Here, we used a novel image-based technique to investigate the mechanical properties of individual cells undergoing CE. Our results suggest a PCP- and Septin-dependent mechanical gradient, where cortical tension is higher at the anterior face of the cells compared with their posterior face. Disruption of PCP protein Vangl2 or its downstream effector Septin7 eliminates this mechanical polarity. These findings demonstrate a link between actin organization, PCP signaling, and mechanical polarization, providing new avenues into the mechanochemical regulation of cellular behaviors during CE.
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