ArticleOsteoarthritis and cartilage2025
The relation of walking forces to structural damage in the knee: The Multicenter Osteoarthritis Study.
Article in Osteoarthritis and cartilage, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Biologics or surgery for moderate knee osteoarthritis? a patient-centered framework for short-term relief and long-term outcomes.Journal of orthopaedic surgery and research · 2026Review
- Relation of vertical ground reaction forces while walking to contralateral structural worsening in adults with unilateral knee osteoarthritis: the Multicenter Osteoarthritis Study.Clinical biomechanics (Bristol, Avon) · 2026Article
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Authors and funding
11 authors.
Funding
Abstract
objectiveMechanical loading is an important, modifiable risk factor for knee osteoarthritis. Identifying walking loads associated with disease worsening presents intervention opportunities. Our purpose was to evaluate the longitudinal relation of the baseline vertical ground reaction force (GRF) during walking to worsening bone marrow lesions (BMLs) and cartilage damage using cohort data from the Multicenter Osteoarthritis Study (MOST).
methodsMOST participants with GRF data at baseline and magnetic resonance imaging examinations at baseline and 2-year follow-up were included. Peak impact force (PIF) and average loading rate (ALR) from the vertical GRF were analyzed with respect to four joint regions (i.e., the medial and lateral portions of the tibiofemoral and patellofemoral joints). Analyses used logistic regression with generalized estimating equations and adjusted for relevant covariates.
resultsHigher PIF was associated with increased odds of worsening BMLs in the lateral patellofemoral joint (odds ratio (95% confidence interval [CI]): 1.33 (1.11, 1.60)) and worsening cartilage damage in the lateral patellofemoral joint (1.48 (1.24, 1.77)), lateral tibiofemoral joint (1.24 (1.03, 1.50)), and medial tibiofemoral joint (1.25 (1.06, 1.48)). Higher ALR was associated with reduced odds of BML worsening in the lateral tibiofemoral joint (0.60 (0.41,0.87)).
conclusionsHigher peak forces when walking were associated with worsening BMLs in the lateral patellofemoral joint and with worsening cartilage damage in regions of the knee associated with higher contact forces during walking. Higher ALRs were not associated with increased odds of structural worsening (BMLs or cartilage).
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