ArticleThe Journal of nutrition2025
The Association Between Prenatal Maternal Selenium Concentration and Neurodevelopment in Early Childhood, Results from a Mother-Child Cohort Study.
Article in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Role of Selenium During Gestation in the Development of Fetal Congenital Anomalies: A Systematic Review.Nutrients · 2026Pooled it
- Early-Life Exposures, Neurodevelopment, and Health Outcomes: Protocol for a Birth Cohort Study.JMIR research protocols · 2026Article
- Prenatal maternal selenium plasma concentration and motor development in early infancy.The British journal of nutrition · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSelenium (Se) is a micronutrient essential for human health and the developing brain. A few studies have demonstrated associations between maternal Se concentration and child neurodevelopment.
objectivesWe aimed to describe Se status in pregnant Nepalese females and explore the association between maternal Se plasma concentration in early pregnancy and child neurodevelopment measured during early childhood in Nepalese children.
methodsThe cohort study included 800 mother-infant dyads from Bhaktapur, Nepal. Blood samples from pregnant females were drawn within 15 wk of gestation and Se concentration was analyzed by inductively coupled plasma mass spectrometry. Child neurodevelopment was assessed at 6, 12, and 24 mo with the Bayley Scales of Infant and Toddler Development, 3rd edition (Bayley-3). We used linear mixed models to examine the association between maternal plasma Se concentration and Bayley-3 scores, adjusted for maternal age and socioeconomic status.
resultsThe mean (standard deviation) maternal plasma Se concentration was 74.8 μg/L (10.4 μg/L), and 290 (36.3%) pregnant females had Se concentration indicating deficiency (<71.1 μg/L). We found no significant association between maternal Se concentration and the Bayley-3 total z-score [Coeff. 0.002 (95% confidence interval: -0.007, 0.011)], and no associations between Se concentration and any of the Bayley-3 composite and subscale scores.
conclusionsDespite a substantial proportion of pregnant females with Se deficiency, maternal Se concentration was not associated with early childhood neurodevelopment in our study cohort of healthy pregnant Nepalese females.
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