ArticleThe American journal of clinical nutrition2025
Dietary intake of polyunsaturated fatty acids, their food sources and fertility in females and males: a preconception prospective population-based cohort study.
Article in The American journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Inflammatory exposures in early pregnancy and multidimensional sleep in late pregnancy: a prospective population-based study.Brain, behavior, & immunity - health · 2026Article
- Nut Consumption and Sperm Quality in Healthy Men: Results From the Led-Fertyl Study.Andrology · 2026Article
- Article
- Diet Quality, Nutrient Intake, and Body Fat Percentage in Women with Infertility and Normal Body Mass Index.Nutrients · 2026Article
- First 1000 Days Strategies to Prevent Childhood Obesity: A Narrative Review and Recommendations From the EndObesity Consortium.Pediatric obesity · 2026Review
- Effects of Germination on the Fatty Acid, Folate, and Mineral Levels in Quinoa.Food science & nutrition · 2025Article
- The Role of Lifestyle Intervention in Female Fertility: A Modifiable Factor for Preconception Health.Nutrients · 2025Review
- Diet and female fertility: a population-based study re-evaluating the need for prescriptive dietary patterns.Frontiers in nutrition · 2025Article
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5 authors.
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Abstract
backgroundSeafood, nuts, and seeds are key dietary sources of polyunsaturated fatty acids (PUFAs), which may benefit reproductive health.
objectivesThis study aims to investigate associations of periconception dietary intake of PUFA-rich foods and omega-3 and omega-6 PUFAs with fecundability and subfertility in females and males.
methodsAmong 830 females and 651 males, participating in a population-based prospective cohort study from preconception onwards, we assessed periconception dietary intake at median 12.4-wk gestation (95% range: 10.9, 18.4) and time to pregnancy via questionnaires. Fecundability was defined as the probability of conceiving within 1 mo and subfertility as time to pregnancy ≥12 mo or use of assisted reproductive technology. Cox proportional hazards and logistic regression were used to assess associations between PUFA(-rich foods) with fecundability and subfertility.
resultsIn females, PUFA-rich food intake was not significantly associated with fertility. Higher omega-3 PUFA intake, especially docosahexaenoic acid and alpha-linolenic acid, but not omega-6 PUFA, was per standard deviation score (SDS) increase associated with increased fecundability and reduced subfertility. Strongest effects were observed for females in the highest quartile. A lower omega-6 to omega-3 PUFA ratio was associated with increased fecundability and lower subfertility risk [fecundability ratio (FR): 0.92, 95% confidence interval (CI): 0.87, 0.96; odds ratio (OR): 1.14, 95% CI: 1.02, 1.26, per unit increase in omega-6:omega-3 PUFA ratio]. In males, higher intake of nuts/seeds, but not seafood, was associated with increased fecundability and lower subfertility (FR: 1.10, 95% CI: 1.01, 1.20; OR: 0.78, 95% CI: 0.63, 0.97 per SDS increase in nuts/seeds). Strongest effects were present for those who consumed the highest amount. No associations were observed for omega-3 or omega-6 PUFA intake in males.
conclusionsIn females, higher dietary omega-3 PUFAs intake may benefit fertility. Increased nuts and seeds consumption may improve fertility in males, independent of PUFA intake. These findings suggest potential for gender-specific dietary interventions to support reproductive health.
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