Evidence map›Paper›PMID 40222388›Full record

ArticleCellular and molecular gastroenterology and hepatology2025

Droplet vs Picowell: Considerations for Single-cell Transcriptomic Profiling of Human Colon Biopsies.

Jonathan M Downie, Ryan J Musich, Connor M Geraghty, Alexander Caraballo, Shijie He, Saleh Khawaled, Kylor Lachut, Julie Y Zhou, Ömer H Yilmaz, Thaddeus S Stappenbeck and 2 more

Abstract read
In one paragraph

Article in Cellular and molecular gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Rapid Research, High Impact: CMGH's Short-Form Initiative.Cellular and molecular gastroenterology and hepatology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jonathan M DownieClinical and Translational Epidemiology Unit, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts; Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts.
Ryan J MusichDepartment of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio.
Connor M GeraghtyClinical and Translational Epidemiology Unit, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts.
Alexander CaraballoClinical and Translational Epidemiology Unit, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts.
Shijie HeClinical and Translational Epidemiology Unit, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts.
Saleh KhawaledKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Kylor LachutClinical and Translational Epidemiology Unit, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts.
Julie Y ZhouDepartment of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio.
Ömer H YilmazKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Thaddeus S StappenbeckDepartment of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio.
Andrew T ChanClinical and Translational Epidemiology Unit, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts; Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts.
David A DrewClinical and Translational Epidemiology Unit, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts; Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address: dadrew@mgh.harvard.edu.

Funding

Training Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3M
Precision Prevention Research ProgramR35CA253185 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Andrew T Chan · 2020 to 2026
$6.9M
Effects of inflammaging on intestinal epithelial cells and aspirin chemoprevention.R01CA257523 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHAN, ANDREW T, STAPPENBECK, THADDEUS S · 2021 to 2025
$3.7M
Impact of Aspirin on the Gut Microbiome and Mucosal MicroenvironmentK01DK120742 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI DREW, DAVID A · 2020 to 2024
$793k
Internalization of dead cells governs intestinal stem cell activityF32DK136180 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI Julie Y. Zhou · 2024 to 2026
$220k
NCI NIH HHS R01 CA257523NCI NIH HHS R35 CA253185NCI NIH HHS T32 CA009001NIDDK NIH HHS F32 DK136180NIDDK NIH HHS K01 DK120742NIDDK NIH HHS L30 DK137289
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40222388
PMCPMC12198022

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.