Evidence map›Paper›PMID 40222047›Full record

ArticleBiomarkers in medicine2025

Immune biomarkers for predicting postoperative pneumonia following hip fracture surgery.

Zemin Wu, Bing Li, Wenke Zhu, JingJing Shang, Jiapei Yao, Yong Huang, Jiansong Yin, Xindie Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomarkers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zemin WuDepartment of Emergency, Wujin Hospital of Traditional Chinese Medicine, Changzhou, Jiangsu, China.
Bing LiDepartment of Orthopedics, Wujin Hospital of Traditional Chinese Medicine, Changzhou, Jiangsu, China.
Wenke ZhuDepartment of Orthopedics, Wujin Hospital of Traditional Chinese Medicine, Changzhou, Jiangsu, China.
JingJing ShangDepartment of Pharmacy, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, China.
Jiapei YaoDepartment of Orthopedics, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou, China.
Yong HuangDepartment of Orthopedics, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou, China.
Jiansong YinDepartment of Neonatology, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, China.
Xindie ZhouDepartment of Orthopedics, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAbnormalities of lymphocyte subsets have been observed in patients with pneumonia. This study investigated the diagnostic efficiency of lymphocyte subsets in the detection of early-stage postoperative pneumonia (POP) among older patients undergoing hip fracture surgery.

methodsA total of 576 patients with hip fracture were recruited and analyzed for lymphocyte subsets on the first postoperative day.

resultsThe incidence of POP was 10.6% (61/576) from March 2016 to December 2023. The area under the curve for the percentage of CD8+ HLA-DR+ T cells was higher than that of CD4+ T and CD4+ CD45RA+ T cells. A high percentage of CD8+ HLA-DR+ T cells was significantly associated with an increased occurrence of POP. The positive findings remained significant after adjusting for confounding factors. Among the multiple complications, patients with diabetes tended to have higher percentages of CD8+ HLA-DR+ T cells.

conclusionsThe percentage of CD8+ HLA-DR+ T cells had a good predictive value for detecting early-stage POP. Multi-center prospective studies with larger sample sizes are needed to verify this finding.

Indexed as

Hip FracturesPneumoniaPostoperative ComplicationsAgedAged, 80 and overBiomarkersCD8-Positive T-LymphocytesFemaleHLA-DR AntigensHumansMaleBiomarkersHLA-DR AntigensbiomarkersHip fractureslymphocyte subsetspneumoniaT cells

Identifiers

PMID40222047
PMCPMC12051530

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.