Evidence map›Paper›PMID 40221965›Full record

ArticleJournal of Parkinson's disease2025

Advice to people with Parkinson's in my clinic: Get a cardiopulmonary exercise test.

Garett J Griffith, Kathleen E McKee, Guillaume Lamotte, Nijee S Luthra, Daniel M Corcos

Abstract read
In one paragraph

Article in Journal of Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Physical Activity and Exercise for People with Parkinson's Disease: The Past, Present, and Future.Movement disorders : official journal of the Movement Disorder Society · 2026
    Review
  2. Review
  3. Frontiers in sports and active living · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Garett J GriffithDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-4243-6676
Kathleen E McKeeIntermountain Health, Neurosciences Clinical Program, Salt Lake City, UT, USA.ORCID 0000-0002-8354-151X
Guillaume LamotteDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0003-4048-6095
Nijee S LuthraDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-6774-0711
Daniel M CorcosDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-7440-6458

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3U01NS113851 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniel M. Corcos · 2019 to 2026
$29.6M
Enhancing Cognitive Resilience In Parkinson's Disease: Role Of Antiaging Protein KlothoK23NS123506 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nijee Luthra · 2022 to 2026
$952k
NCATS NIH HHS UL1 TR001422NINDS NIH HHS K23 NS123506NINDS NIH HHS U01 NS113851
6 · The paper itself

Abstract

Aerobic (cardiopulmonary) exercise training improves fitness and limits the progression of motor signs in Parkinson's disease. Individualized development of exercise prescriptions relies upon accurately measured peak heart rate (HR). Cardiopulmonary exercise testing (CPET) is the only methodology to objectively confirm an individual's peak HR. This test is important in individuals who may have autonomic dysfunction, which may manifest as chronotropic incompetence. Without CPET's confirmation of maximal effort, there is no way of knowing whether exercise prescription in those with chronotropic incompetence is accurate. CPET also provides information regarding cardiorespiratory fitness, which can motivate patients to exercise to prolong health.

Indexed as

Cardiorespiratory FitnessExercise TestExercise TherapyParkinson DiseaseHeart RateHumansautonomic dysfunctioncardiopulmonary exercise testingcardiorespiratory fitnessexercise trainingpeak heart rate

Identifiers

PMID40221965
PMCPMC12911533

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.