ArticleArchives of toxicology2025
Alterations in acetylcholinesterase activity and oxidative stress parameters induced by pure cylindrospermopsin in brain of orally exposed rats and determination of potential metabolites.
Article in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Cylindrospermopsin toxicokinetics: in silico ADMET modeling, rat and human liver microsome metabolism, and UHPLC-MS/MS metabolite characterization.Archives of toxicology · 2026Article
- Omics Insights into Cylindrospermopsin's Molecular Toxicity.Foods (Basel, Switzerland) · 2025Review
- Article
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4 authors.
Funding
Abstract
Cylindrospermopsin (CYN) is a secondary metabolite produced by cyanobacteria. In view of its toxic effects, CYN is frequently classified as a cytotoxin, although it has been associated with neurotoxicological effects. Despite this, few studies have explored the impact of CYN on the nervous system and none of them have been conducted in mammals. Therefore, the objective of the present work was to evaluate the effect of different doses of pure CYN (7.5-75.0 µg/kg body weight) on the brain of rats after gavage exposure for 48 h. For this purpose, the activity of acetylcholinesterase (AChE) enzyme and different biomarkers of oxidative stress were assessed. A significant inhibition of AChE activity was observed at all doses tested. Additionally, the results showed a dose-dependent increase in lipid peroxidation (LPO) levels, as well as alterations in superoxide dismutase (SOD) and catalase (CAT) activities. These changes could be produced by CYN metabolites detected in brain samples by ultra-high-performance liquid chromatography coupled to a tandem mass spectrometry system (UHPLC-MS/MS). These findings suggest that metabolites of pure CYN could cause alterations in the brain of rats after oral exposure and highlight the need for further studies focusing on CYN's neurotoxicity and its potential role in neurodegenerative diseases.
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