Evidence map›Paper›PMID 40221765›Full record

ArticleBMC complementary medicine and therapies2025

Quorum sensing inhibition by South African medicinal plants species: an in vitro and an untargeted metabolomics study.

Phanankosi Moyo, Olusola Bodede, Madelien Wooding, Ibukun M Famuyide, Fikile N Makhubu, Ndivhuwo K Khorommbi, Michael Ofori, Cynthia A Danquah, Lyndy J McGaw, Vinesh J Maharaj

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In one paragraph

Article in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Phanankosi MoyoBiodiscovery Center, Department of Chemistry, University of Pretoria, Hatfield, Pretoria, 0028, South Africa.
Olusola BodedeBiodiscovery Center, Department of Chemistry, University of Pretoria, Hatfield, Pretoria, 0028, South Africa.
Madelien WoodingBiodiscovery Center, Department of Chemistry, University of Pretoria, Hatfield, Pretoria, 0028, South Africa.
Ibukun M FamuyidePhytomedicine Programme, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, Pretoria, 0110, South Africa.
Fikile N MakhubuPhytomedicine Programme, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, Pretoria, 0110, South Africa.
Ndivhuwo K KhorommbiBiodiscovery Center, Department of Chemistry, University of Pretoria, Hatfield, Pretoria, 0028, South Africa.
Michael OforiDepartment of Pharmaceutical Sciences, Dr Hilla Limann Technical University, Wa, Ghana.
Cynthia A DanquahDepartment of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, PMB, Kumasi, Ghana.
Lyndy J McGawPhytomedicine Programme, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, Pretoria, 0110, South Africa. lyndy.mcgaw@up.ac.za.
Vinesh J MaharajBiodiscovery Center, Department of Chemistry, University of Pretoria, Hatfield, Pretoria, 0028, South Africa. vinesh.maharaj@up.ac.za.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe emergence of antimicrobial resistance (AMR) is imperiling global health, hence, the need to remedy this challenge by discovering new therapeutic strategies and agents. Quorum sensing inhibition (QSI) is opined as a potential novel strategic approach in the fight against AMR by abrogation of bacterial virulence and pathogenicity. Currently, there are no clinically approved QSI drugs. Based on this, this study evaluated the QSI properties of South African plant species.

methodsTwenty-nine extracts and their corresponding 203 fractions generated using solid phase extraction were screened for QSI activity in vitro against Chromobacterium violaceum ATCC 12472. Active and inactive fractions of the most potent plant species were analysed using UPLC-HRMS. The acquired mass spectral data was subjected to chemometric analysis.

resultsFrom the QSI assays, three plant species showed remarkable QSI activity, measured by dose-dependent inhibition of violacein production (IVP), at sublethal concentrations. Terminalia phanerophlebia emerged as the most active species, with the extract and five of its fractions showing good activity in IVP (IVP IC

conclusionIn conclusion, the findings of our study provided insight into the QSI properties of South African plant species. Further studies will focus on the isolation of the putative active compounds and the in vitro evaluation of their QSI activity.

Indexed as

Anti-Bacterial AgentsChromobacteriumPlant ExtractsPlants, MedicinalQuorum SensingIndolesMetabolomicsSouth AfricaAnti-Bacterial AgentsIndolesPlant ExtractsviolaceinAntimicrobial drug resistanceChromobacterium violaceumMetabolomicsNatural productsPlantsQuorum sensing

Identifiers

PMID40221765
PMCPMC11994000

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.