Evidence map›Paper›PMID 40221742›Full record

SynthesisWorld journal of emergency surgery : WJES2025

A systematic review of the predictive factors for the recurrence of acute pancreatitis.

Daniela Pacella, Adriano De Simone, Adolfo Pisanu, Gianluca Pellino, Lucio Selvaggi, Valentina Murzi, Eleonora Locci, Giulia Ciabatti, Laura Mastrangelo, Elio Jovine and 35 more

Abstract readSystematic Review
In one paragraph

Synthesis in World journal of emergency surgery : WJES, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors.

Daniela Pacella *Department of Public Health, University of Naples Federico II, Naples, Italy.
Adriano De Simone *Department of Public Health, University of Naples Federico II, Naples, Italy.
Adolfo PisanuEmergency Surgery Unit, Department of Surgical Science, University of Cagliari, Cagliari, Italy.
Gianluca PellinoDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Lucio SelvaggiDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Valentina MurziEmergency Surgery Unit, Department of Surgical Science, University of Cagliari, Cagliari, Italy.
Eleonora LocciEmergency Surgery Unit, Department of Surgical Science, University of Cagliari, Cagliari, Italy.
Giulia CiabattiDepartment of Medical and Surgical Science, University of Bologna, Maggiore Hospital, Bologna, Italy.
Laura MastrangeloDepartment of Medical and Surgical Science, University of Bologna, Maggiore Hospital, Bologna, Italy.
Elio JovineDepartment of Medical and Surgical Science, University of Bologna, Maggiore Hospital, Bologna, Italy.
Matteo RottoliDepartment of Medical and Surgical Science, University of Bologna, Sant'Orsola Hospital, Bologna, Italy.
Giacomo CaliniDepartment of Medical and Surgical Science, University of Bologna, Sant'Orsola Hospital, Bologna, Italy.
Stefano CardelliDepartment of Medical and Surgical Science, University of Bologna, Sant'Orsola Hospital, Bologna, Italy.
Fausto CatenaDepartment of General, Emergency and Trauma Surgery, Bufalini Hospital, Cesena, Italy.
Carlo VallicelliDepartment of General, Emergency and Trauma Surgery, Bufalini Hospital, Cesena, Italy.
Raffaele BovaDepartment of General, Emergency and Trauma Surgery, Bufalini Hospital, Cesena, Italy.
Gabriele ViguttoDepartment of General, Emergency and Trauma Surgery, Bufalini Hospital, Cesena, Italy.
Fabrizio D'AcapitoDepartment of Medical and Surgical Science, University of Bologna, Morgagni-Pierantoni Hospital Forlì, Forlì, Italy.
Giorgio ErcolaniDepartment of Medical and Surgical Science, University of Bologna, Morgagni-Pierantoni Hospital Forlì, Forlì, Italy.
Leonardo SolainiDepartment of Medical and Surgical Science, University of Bologna, Morgagni-Pierantoni Hospital Forlì, Forlì, Italy.
Alan BiloslavoDepartment of General Surgery, Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste, Trieste, Italy.
Paola GermaniDepartment of General Surgery, Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste, Trieste, Italy.
Camilla ColuttaDepartment of General Surgery, Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste, Trieste, Italy.
Pasquale LepianeDepartment of Surgery, San Paolo Hospital Civitavecchia, Rome, Italy.
Rosa ScaramuzzoDepartment of Surgery, San Paolo Hospital Civitavecchia, Rome, Italy.
Savino OcchionorelliDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Domenico LacavallaDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Maria Grazia SibillaDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Stefano OlmiDepartment of General Surgery, San Donato Hospital Zingonia, Bergamo, Italy.
Matteo UccelliDepartment of General Surgery, San Donato Hospital Zingonia, Bergamo, Italy.
Alberto OldaniDepartment of General Surgery, San Donato Hospital Zingonia, Bergamo, Italy.
Alessio GiordanoDepartment of Emergency Surgery, Careggi Hospital, Firenze, Italy.
Tommaso GuagniDepartment of Emergency Surgery, Careggi Hospital, Firenze, Italy.
Davina PeriniDepartment of Emergency Surgery, Careggi Hospital, Firenze, Italy.
Francesco PataDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
Bruno NardoDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
Daniele PaglioneDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
Giusi FrancoDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
Matteo DonadonDepartment of Health Science, University of Piemonte Orientale, Ospedale Maggiore della Carità, Novara, Italy.
Marcello Di MartinoDepartment of Health Science, University of Piemonte Orientale, Ospedale Maggiore della Carità, Novara, Italy.
Salomone Di SaverioDepartment of Surgery, Madonna del Soccorso Hospital, San Benedetto del Tronto, Italy.
Luca CardinaliDepartment of Surgery, Madonna del Soccorso Hospital, San Benedetto del Tronto, Italy.
Grazia TravagliniDepartment of Surgery, Madonna del Soccorso Hospital, San Benedetto del Tronto, Italy.
Dario BruzzeseDepartment of Public Health, University of Naples Federico II, Naples, Italy.
Mauro PoddaEmergency Surgery Unit, Department of Surgical Science, University of Cagliari, Cagliari, Italy. mauro.podda@unica.it.

Funding

European Union (NextGenerationEU) and MUR (Italian Ministry of University and Research) within the program "Progetti di Rilevante Interesse Nazionale" (PRIN) 2022 202273A4YP
6 · The paper itself

Abstract

purposeAcute Pancreatitis (AP) is a prevalent clinical pancreatic disorder characterized by acute inflammation of the pancreas, frequently associated with biliary or alcoholic events. If not treated with cholecystectomy after the first episode, patients may experience a recurrence of AP, with consequent need for emergency surgery and increased risk of death. Analyzing the risk factors that may contribute to the recurrence of Biliary and Alcoholic Pancreatitis (BAP and AAP), future research can be driven toward new solutions for preventing and treating this pancreatic disease.

methodsA systematic review was conducted selecting studies from BiomedCentral, PubMed, Scopus and Web of Science by two independent reviewers. Publications were considered only if written in English in the time interval between January 2000 and June 2024 and investigated the risk factors for the recurrence of BAP and AAP. At the end of the selection, a quality assessment phase was conducted using the PROBAST tool.

resultsIn this systematic review, 8 articles were selected out of 6.945, involving a total sample of 11.271 patients of which 38.77% developed recurrence episodes. 37.5% of the included studies focus on recurrent acute biliary pancreatitis (RBAP), while 62.5% are dedicated to recurrent acute alcoholic pancreatitis (RAAP). The risk factors for the recurrence of AP showed a clear differentiation between the alcoholic and biliary etiology. Most of the considered studies adopted a retrospective design, characterized by a susceptibility to potential methodological biases. However, the trend indicated a more recent increase in prospective studies, together with a greater focus on identifying and understanding the possible risk factors associated with the recurrence of acute pancreatitis (RAP). This result highlighted the progress in the scientific approach toward a more rigorous and systematic assessment of the causes and dynamics that influence the recurrence of the disease.

conclusionStudies highlighted the importance of lifestyle factors, clinical complications, and surgical interventions that can impact the risk of biliary or alcoholic recurrent acute pancreatitis. Increased and systematic adoption of artificial intelligence-based tools could significantly impact future knowledge relating to the risks of recurrence and relative possibilities of prevention.

Indexed as

PancreatitisAcute DiseaseHumansRecurrenceRisk FactorsAcute PancreatitisAlcoholicBiliaryRecurrenceRisk factors

Identifiers

PMID40221742
PMCPMC11994023

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.