The characteristics of peripheral blood lymphocyte main subsets in rheumatoid arthritis patients concurrent with hepatitis b virus infection: a retrospective cohort study.

Lijia Shao, Lihong Shen, Junqi Wu

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Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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3 authors.

Lijia Shao *Department of Clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, China.

Lihong Shen *Department of Clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, China.

Junqi WuDepartment of Clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, China. junqiwu_0107@163.com.

Funding

Jinhua Central Hospital JY2021-1-04Jinhua Science and Technology Research Project 2021 2021-4-009

6 · The paper itself

Abstract

objectiveThe distribution of peripheral blood lymphocytes may change due to the influence of diseases. This study aims to investigate the impact of Hepatitis B virus (HBV) infection on the distribution of peripheral blood lymphocyte subsets in patients with Rheumatoid Arthritis (RA).

methodsTwo hundred ninety-eight patients were recruited from a retrospective cohort of patients with RA. Patients with RA (n = 43) who had hepatitis B surface antigen (HBsAg) positivity in the serum were categorized into the HBV group (HBV-RA group), while 255 RA patients without HBsAg positivity were assigned to the control group. The patients in the HBV-RA group were further divided into two subgroups based on their levels of HBV DNA: those with levels below the lower limit of quantification (< 20 IU/ml) formed the HBV DNA

resultsCompared with those of the control group, a higher proportion of CD19

conclusionThe high proportion of CD19 + B and CD8 + T cells were closely associated with RA concurrent with HBV infection.

Indexed as

Arthritis, RheumatoidHepatitis BLymphocyte SubsetsAdultAgedCD8-Positive T-LymphocytesDNA, ViralFemaleHepatitis B Surface AntigensHepatitis B virusHumansMaleMiddle AgedRetrospective StudiesDNA, ViralHepatitis B Surface AntigensHepatitis B virusInfectionPeripheral blood lymphocytesRheumatoid arthritis

Identifiers

PMID40221696

DOI10.1186/s12879-025-10932-4

PMCPMC11994019

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