Evidence map›Paper›PMID 40221691›Full record

SynthesisBMC gastroenterology2025

Unfavorable outcomes and their predictors in patients treated for perforated peptic ulcer disease in Ethiopia: systematic review and meta-analysis.

Destaw Endeshaw, Ousman Adal, Abiyu Abadi Tareke, Natnael Kebede, Amare Mebrat Delie, Eyob Ketema Bogale, Tadele Fentabel Anagaw, Misganaw Guadie Tiruneh, Eneyew Talie Fenta

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Destaw EndeshawDepartment of Adult Health Nursing, School of Health Science, College of Medicine and Health Science, Bahir Dar University, 79, Bahir Dar, Ethiopia. destaw.endeshaw@bdu.edu.et.
Ousman AdalDepartment of Emergency and Critical Care Nursing, School of Health Science, College of Medicine and Health Science, Bahir Dar University, 79, Bahir Dar, Ethiopia.
Abiyu Abadi TarekeCOVAX/Routine Immunization Technical Assistant, West Gondar Zonal Health Department, Amhara Regional Health Bureau, Gendawuha, Ethiopia.
Natnael KebedeDepartment of Health Promotion, School of Public Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Amare Mebrat DelieDepartment of Public Health, College of Medicine and Health Science, Injibara University, Injibara, Ethiopia.
Eyob Ketema BogaleHealth Promotion and Behavioral Science Department, College of Medicine and Health Science, Bahir Dar University, 79, Bahir Dar, Ethiopia.
Tadele Fentabel AnagawHealth Promotion and Behavioral Science Department, College of Medicine and Health Science, Bahir Dar University, 79, Bahir Dar, Ethiopia.
Misganaw Guadie TirunehDepartment of Health Systems and Policy, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Eneyew Talie FentaDepartment of Public Health, College of Medicine and Health Science, Injibara University, Injibara, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPerforated peptic ulcer (PPU) is a surgical emergency condition associated with substantial mortality and morbidity. Despite scattered studies, there exists a gap in comprehensive evidence on management outcomes of this condition in Ethiopia. Hence, this review aimed to assess the pooled mortality and complication rates along with their predictors in patients treated for PPU.

methodsIn this review, an extensive search across various electronic databases including PubMed, Africa Index Medicus, Science Direct, and Hinari was conducted. Additionally, searches were conducted in Google Scholar and online library repositories of Addis Ababa, Hawassa, and Bahir Dar Universities, complemented by manual searches of included studies. Data extraction was performed using Excel and the analysis was done using STATA 17 software. Pooled estimates of mortality and complication rates were determined using a random-effect model, while associated predictors were identified through the analysis using a fixed-effect model. Subgroup analysis for mortality rate was conducted by region. Sensitivity analysis was performed after assessing heterogeneity using the I

resultsThis meta-analysis, encompassing 9 studies, revealed a pooled mortality rate of 6.68% (95% CI: 4.36, 9.00) with a high level of heterogeneity (I

conclusionIn Ethiopia, morbidity and mortality following PPU management are significant, influenced by delayed presentation, low systolic blood pressure, and advanced age. Timely interventions, early hemodynamic stabilization, and age-specific considerations are vital to improving outcomes. PROTOCOL REGISTRATION NUMBER: CRD42024497946.

Indexed as

Peptic Ulcer PerforationPostoperative ComplicationsEthiopiaHumansRisk FactorsEthiopiaFactorsMeta-analysisMorbidityMortalityPUD

Identifiers

PMID40221691
PMCPMC11992735

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.