Evidence map›Paper›PMID 40221636›Full record

ArticleBone marrow transplantation2025

Food insecurity prior to hematopoietic stem cell transplant is associated with malnutrition and worse outcomes.

Matthew A Bergens, Yen P Lowder, Yan Li, Ernaya J Johnson, Hilary M Winthrop, Amy T Bush, Angela Xiong, Lauren Hill, Isabella Gorski, Bethany Weaver and 14 more

Abstract read
PubMed Publisher
In one paragraph

Article in Bone marrow transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Matthew A Bergens *Duke University School of Medicine, Durham, NC, USA.
Yen P Lowder *Department of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA.
Yan LiDuke Cancer Institute Biostatistics Shared Resource, Duke University, Durham, NC, USA.
Ernaya J JohnsonDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0001-8249-6801
Hilary M WinthropDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA.
Amy T BushDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA.
Angela XiongDuke University, Durham, NC, USA.
Lauren HillDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA.
Isabella GorskiDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA.
Bethany WeaverDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA.
S Yousuf ZafarDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA.
Edwin P AlyeaDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA.
Nelson J ChaoDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0001-6725-7220
Taewoong ChoiDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0003-3776-2407
Cristina GasparettoDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA.
Sanghee HongDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA.
Mitchel E HorwitzDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0001-9863-8464
Chenyu LinDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0002-4542-4232
Gwynn D LongDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA.
Richard D LopezDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA.
Sendhilnathan RamalingamDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA.
Stefanie SarantopoulosDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA.
Keith M SullivanDepartment of Medicine, Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0002-1379-9216
Anthony D SungDivision of Hematologic Malignancies and Cellular Therapy, University of Kansas Medical Center, Westwood, KS, USA. asung2@kumc.edu.ORCID http://orcid.org/0000-0003-3765-641X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Food insecurity (FI), defined as the lack of continuous access to adequate food, affects 17-55% of cancer patients. Effects may be exacerbated in hematopoietic stem cell transplant (HSCT) patients, who face nutritional challenges due to treatment side effects, leading to weight loss and malnutrition. We hypothesize that pre-HSCT FI increases the risk of malnutrition, requiring nutrition support, and adverse psychosocial outcomes. Between February 2018 and August 2022, 284 patients were screened before HSCT for FI. 71 (25%) were excluded due to missing data. Of the remaining 213, 20 (9.4%) reported pre-HSCT FI. Patients with FI were more likely to develop malnutrition during HSCT (70% vs. 45.1%, p = 0.034) and need total parenteral nutrition compared to those without FI (65% vs. 34.2%, p = 0.013). Patients with FI also were more likely to screen positive for depression (40% vs. 10.4%, p = 0.002) and financial toxicity (75% vs. 25%, p < 0.001). There were no significant differences in survival or other secondary outcomes. Our study demonstrates that pre-HSCT FI significantly increases likelihood of malnutrition, the need for total parenteral nutrition, and adverse psychosocial outcomes in HSCT patients. These findings highlight the critical importance of early identification and interventions to address FI as part of comprehensive cancer care.

Indexed as

Food InsecurityHematopoietic Stem Cell TransplantationMalnutritionAdultAgedFemaleHumansMaleMiddle Aged

Identifiers

PMID40221636

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.