ArticleScientific reports2025
Semi-automated evaluation of trabecular meshwork and schlemm canal imaged with OCT in children with normal eyes vs. primary congenital glaucoma.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Maldevelopment of Schlemm canal (SC) and trabecular meshwork (TM) is proposed in the pathogenesis of primary congenital glaucoma (PCG). This study aims to evaluate a semi-automated segmentation algorithm of SC and TM in pediatric patients scanned using overhead-mounted optical coherence tomography (OCT). Twenty-four children (33 eyes: 17 PCG, 16 normal), with mean age 1.3 ± 1.08 years, had anterior segment OCT imaging. Manual segmentation of SC and TM on individual B-scans represented the gold standard and was compared to semi-automated segmentation of the same structures. Intraclass correlation (ICC) compared the manual and semi-automated algorithm for several parameters: SC area (0.940), circularity (0.742), and aspect ratio (0.861); and TM thickness (0.807). Comparing eyes with PCG vs. normal, we found: (1) decreased SC area (4084 ± 4553µm
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