Evidence map›Paper›PMID 40221570›Full record

ArticleDiscover oncology2025

Fulvic acid exhibits antitumor effects in ovarian cancer cells by upregulating cytochrome P450 family 1 subfamily A member 1 expression.

Min Chen, Ming Cheng, Chenchen Shao, Wenwen Liang, Yi Tang, Fangjun Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Min Chen *Shandong Agricultural University Fertilizer Science & Technology Co., Ltd, No. 249 Chuangye Road, Feicheng City, Tai'an, 271608, China.
Ming Cheng *Department of Gastrointestinal Surgery, The Affiliated Tai'an City Central Hospital of Qingdao University, Tai'an, 271000, China.
Chenchen ShaoDepartment of Obstetrics and Gynecology, The Affiliated Tai'an City Central Hospital of Qingdao University, Tai'an, 271000, China.
Wenwen LiangDepartment of Obstetrics and Gynecology, The Affiliated Tai'an City Central Hospital of Qingdao University, Tai'an, 271000, China.
Yi TangCollege of Animal Science and Technology, Shandong Agricultural University, No. 61 Daizong Street, Taishan District, Tai'an, 271018, China. tyck288@sdau.edu.cn.
Fangjun DingShandong Agricultural University Fertilizer Science & Technology Co., Ltd, No. 249 Chuangye Road, Feicheng City, Tai'an, 271608, China. dfj401@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveFulvic acid (FA), a humic substance, has various applications in agricultural (animal husbandry) and pharmaceutical industries. However, to the best of our knowledge, its antitumor effects remain unclear. This study aimed to elucidate the effects and underlying mechanisms of FA in ovarian cancer cells.

methodsTo determine the half-maximal inhibitory concentration (IC

resultsThe IC

conclusionFA suppressed cell proliferation, invasion, and migration and upregulated CYP1A1 expression in SK-OV-3 and OVCAR3 cells. Our results suggest that FA demonstrates antitumor effects in ovarian cancer cells through CYP1A1 regulation.

Indexed as

Cytochrome P450 CYP1A1Fulvic acidOvarian cancerRNA sequencing

Identifiers

PMID40221570
PMCPMC11993516

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.