Maternal obesity and ancestry distance in influencing birth outcomes.

Randy Le, Richard J Biedrzycki, Fasil Tekola-Ayele

Registry-linked trialAbstract readObservational Study

In one paragraph

Observational study in International journal of obesity (2005), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00912132 (The National Standard for Normal Fetal Growth), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00912132 completednot on this map

The National Standard for Normal Fetal Growth

TypeobservationalSponsorEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Ran2009 to 2013Enrolled2,802ConditionsPregnancy, Fetal Growth

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Randy LeEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-9102-7409

Richard J BiedrzyckiGlotech, Inc., contractor for Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Fasil Tekola-AyeleEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. ayeleft@mail.nih.gov.ORCID 0000-0003-4194-9370

Funding

NICHD NIH HHS HHSN275201000009CNIH HHS HHSN27500008, HHSN27500006NIH HHS HHSN275200800003IC; HHSN275200800014CNIH HHS HHSN275200800012C; HHSN275200800028CNIH HHS HHSN275200800013C; HHSN275200800002I

6 · The paper itself

Abstract

backgroundMaternal pre-pregnancy obesity has been associated with birth outcomes, but the influence of genetic distance (GD) on this relationship is unclear. Therefore, the objective of this study was to assess the interplay of GD and maternal obesity on birthweight, placental weight, and large for gestational age (LGA).

methodsWe used data from the NICHD Fetal Growth Studies-Singletons cohort, a prospective cohort study of multi-ancestral pregnant women. GD was estimated using data from 1810 women across four ancestral reference populations. We categorized GD into five quintiles, with quintile one and quintile five representing the closest and farthest distances, respectively. Linear regression models were used to test association between GD and birth outcomes and to estimate the association of interaction of GD and maternal obesity with birth outcomes.

resultsFarther maternal GD from an African reference was significantly associated with higher birthweight and higher odds of LGA, with associations persisting after adjusting for socioeconomic status (SES). The interaction between the third Amerindigenous GD quintile and obesity was significantly associated with a 198 g larger placental weight (95% CI = 51-345, p = 0.009) compared to the first Amerindigenous GD quintile. We also found the interaction between East Asian fourth GD quintile and obesity to be significantly associated with 86.0% lower odds of infants being born LGA (OR = 0.14 g, 95% CI = 0.02-74, p = 0.031) compared to the first quintile. These associations persisted after SES adjustment.

conclusionsInterplays between maternal GD from Amerindigenous and East Asian references and pre-pregnancy obesity influence placental weight and risk of LGA. The results underline that consideration of maternal obesity in the context of GD from multiple ancestries and SES may facilitate interventions that will minimize adverse pregnancy outcomes. CLINICAL

trial registrationThe study has been registered at ClinicalTrials.gov (Trial registration: NCT00912132).

Indexed as

Birth WeightObesityPregnancy in ObesityPregnancy OutcomeAdultFemaleHumansInfant, NewbornPlacentaPregnancyProspective StudiesReference ValuesUnited States

Identifiers

PMID40221546

DOI10.1038/s41366-025-01783-9

What OpenQuestion holds

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Registered trials

NCT00912132ClinicalTrials.gov

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.